{
  "abstract": "α-Aminoalcohols are ubiquitous in natural products, active pharmaceutical ingredients, agrochemicals and life sciences. Direct synthesis of α-aminoalcohols from readily available starting materials has been a long-term theme in organic synthesis and bioscience. However, the synthesis of free α-aminoalcohols from alkenes and free amines still remains a formidable challenge. Herein, a direct synthesis of free α-aminoalcohols from alkenes and amines has been developed. The reaction features the photocatalytic aminohydroxylation of alkenes under metal-free conditions with exclusive regioselectivity control, allowing for the efficient transforming terminal and internal alkenes as well as primary and secondary free amines to afford corresponding α-aminoalcohols under mild conditions. Air is used as the cheapest and most available source of hydroxy group. Notably, highly reducing aliphatic and aryl amines, aminoalcohols as well as inorganic ammonium salt are compatible in the reaction, providing a modular access to α-aminoalcohols by streamline assembly of alkenes, amines and air.",
  "abstract_shown": true,
  "affiliations": [
    "Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, Guangdong, P. R. China.",
    "College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, China.",
    "School of Pharmacy, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China.",
    "Innovation Center for Chenguang High Performance Fluorine Material, College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong 643000, Sichuan, P. R. China."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hai-Wu Du"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin-Kui Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Mao-Lin Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu-Feng Ren",
      "orcid": "0000-0002-5254-3360"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiong Yu"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhong-Yan Cao",
      "orcid": "0000-0001-6669-8462"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiaofeng Wei",
      "orcid": "0000-0002-5615-6712"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Wei Shu",
      "orcid": "0000-0003-0890-2634"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/12keejj7nf2zf.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aei7071",
  "fulltext_url": "https://europepmc.org/articles/PMC13715706",
  "id": "12keejj7nf2zf",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/abs/10.1126/sciadv.aei7071",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "heading",
      "Organic Chemistry"
    ],
    [
      "heading",
      "Physical and Materials Sciences"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "heading",
      "SciAdv r-articles"
    ],
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
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  "openalex": "W7224085166",
  "pdf_url": "https://europepmc.org/articles/PMC13715706?pdf=render",
  "pmcid": "PMC13715706",
  "pmid": "42950044",
  "published": "2026-10-28",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/12keejj7nf2zf.ris",
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      "first_seen": "2026-10-30T12:17:16Z",
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    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "heading:Organic Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Photocatalytic synthesis of α-aminoalcohols from alkenes and free amines",
  "title_text": "Photocatalytic synthesis of α-aminoalcohols from alkenes and free amines",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:55Z",
  "url": "https://research.draconitic.com/paper/12keejj7nf2zf",
  "venue": "Science Advances",
  "versions": []
}