{
  "abstract": "Acute-on-chronic liver failure is a severe syndrome with high short-term mortality, and current treatments are limited to liver transplantation and supportive care. Here we show that EP300 inhibition alleviates acute-on-chronic liver failure by targeting scar-associated macrophages, a subset that proliferates during disease progression and whose impaired antibacterial function is linked to poor prognosis. EP300 inhibition enhances the antibacterial activity of scar-associated macrophages through transcriptional repression of ACOD1. ACOD1 expression is induced in scar-associated macrophages during acute-on-chronic liver failure, and its loss mitigates hepatic destruction and prolongs survival in male mice with acute-on-chronic liver failure by enhancing the phagocytic function of scar-associated macrophages. These findings suggest that EP300 inhibition alleviates acute-on-chronic liver failure through ACOD1-dependent reprogramming of scar-associated macrophages, providing a promising therapeutic strategy for acute-on-chronic liver failure.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "name": "Panyu Chen",
      "orcid": "0009-0006-9134-5881"
    },
    {
      "name": "Bingyuan Huang"
    },
    {
      "name": "Wentao Chen",
      "orcid": "0000-0002-3237-2568"
    },
    {
      "name": "Xiao Lin"
    },
    {
      "name": "Changjie Yang"
    },
    {
      "name": "Chen Wang"
    },
    {
      "name": "Wenxi Su"
    },
    {
      "name": "Zhaokai Zeng"
    },
    {
      "name": "Yunyun Ren"
    },
    {
      "name": "Shijie Fan"
    },
    {
      "name": "Yun Song"
    },
    {
      "name": "Rong Fu"
    },
    {
      "name": "Yixuan Xu"
    },
    {
      "name": "Xiaosong Chen"
    },
    {
      "name": "Xiaogang Xiang",
      "orcid": "0000-0003-0999-2950"
    },
    {
      "name": "Guangming Li"
    },
    {
      "name": "Kaixian Chen"
    },
    {
      "name": "Xiong Ma",
      "orcid": "0000-0001-9616-4672"
    },
    {
      "name": "Yugang Wang",
      "orcid": "0000-0001-5675-2509"
    },
    {
      "name": "Yuanyuan Zhang"
    },
    {
      "name": "Min Shi"
    },
    {
      "name": "Cheng Luo",
      "orcid": "0000-0003-3864-8382"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/12w61vscejxy2.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78245-x",
  "fulltext_url": null,
  "id": "12w61vscejxy2",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78245-x",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2721|Liver physiology and pathology"
    ]
  ],
  "openalex": "W7220837794",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78245-x_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/12w61vscejxy2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-78245-x",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78245-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver physiology and pathology",
      "subfield": "general"
    }
  ],
  "title": "EP300 inhibition alleviates acute-on-chronic liver failure through modulation of scar-associated macrophages",
  "title_text": "EP300 inhibition alleviates acute-on-chronic liver failure through modulation of scar-associated macrophages",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/12w61vscejxy2",
  "venue": "Nature Communications",
  "versions": []
}