{
  "abstract": "Background and purpose: Previous studies have linked lipid measures to hematoma expansion and outcomes after intracerebral hemorrhage (ICH), but prognostic evidence for the apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio remains limited. We examined the associations of acute-phase ApoB/ApoA1 with 90-day mortality and poor functional outcome after primary ICH and evaluated its incremental prognostic information beyond the ICH score.\n\nMethods: We conducted a single-center observational cohort study of adults with primary ICH who underwent baseline CT within 72 h after symptom onset. The primary outcome was 90-day all-cause mortality; the secondary outcome was poor functional outcome at 90 days. Logistic regression examined associations of ApoB/ApoA1 with outcomes in unadjusted and ICH score-adjusted models. Incremental value beyond the ICH score was assessed using discrimination, Brier score, calibration, and bootstrap internal validation.\n\nResults: Among 470 included patients, 73 (15.5%) died and 190 (40.4%) had poor functional outcome at 90 days. Higher ApoB/ApoA1 was associated with lower 90-day mortality after adjustment for the ICH score (OR per 0.1-unit increase, 0.82; 95% CI, 0.71–0.96; p = 0.012), but not with poor functional outcome (OR, 0.97; 95% CI, 0.90–1.06; p = 0.531). Adding ApoB/ApoA1 to the ICH score yielded a limited increase in discrimination for 90-day mortality (ΔAUC, 0.027; bootstrap 95% CI, 0.008–0.057; likelihood-ratio p = 0.008), with little change in Brier score or calibration. No meaningful improvement was observed for poor functional outcome.\n\nConclusion: Higher acute-phase ApoB/ApoA1 was associated with lower 90-day mortality, but not poor functional outcome, after accounting for the ICH score. ApoB/ApoA1 provided limited incremental prognostic information for 90-day mortality beyond the ICH score. Clinical usefulness remains uncertain, and external validation is needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, The First Affiliated Hospital of Chongqing Medical University",
    "Department of Radiology, Chongqing University Fuling Hospital",
    "Department of Neurology, University-Town Hospital of Chongqing Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jun-Meng Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yong-Bo Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Shu-Qiang Zhang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Chao-Yi Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Rui Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "You-Dong Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Wen-Song Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/130k2pdhav6t2.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1898784",
  "fulltext_url": null,
  "id": "130k2pdhav6t2",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1898784/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/130k2pdhav6t2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1898784",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1898784/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2295",
      "subfield": "neurology"
    }
  ],
  "title": "Association of the apolipoprotein B/apolipoprotein A1 ratio with 90-day mortality after acute intracerebral hemorrhage: a single-center cohort study",
  "title_text": "Association of the apolipoprotein B/apolipoprotein A1 ratio with 90-day mortality after acute intracerebral hemorrhage: a single-center cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:21:08Z",
  "url": "https://research.draconitic.com/paper/130k2pdhav6t2",
  "venue": "Frontiers in Neurology",
  "versions": []
}