{
  "abstract": "Background\n\nStudies have indicated that maternal anxiety and depression during pregnancy can contribute to neurodevelopmental disorders and gut flora dysbiosis in children. However, it is unclear whether these factors increase the risk of autism spectrum disorder (ASD) with gastrointestinal (GI) symptoms in children.Objective\n\nThis study aimed to analyze the relationship between maternal anxiety and depression during pregnancy and ASD with GI symptoms.Methods\n\nA total of 470 children with ASD and 486 children with typical development were enrolled in the study. The caregivers of all enrolled children completed questionnaires, including information on maternal mental health and GI symptoms.Results\n\nThe percentage of maternal prenatal anxiety or depression was significantly higher in the ASD group than in the typical development group (P<.001). Children whose mothers experienced anxiety or depression during pregnancy had substantially higher risk of developing ASD than those whose mothers did not experience these conditions (unadjusted odds ratio [OR] 4.274, 95% CI 2.799-6.526; adjusted OR 3.897, 95% CI 2.481-6.119). For children with ASD, those whose mothers had prenatal anxiety or depression had a significantly higher risk of GI symptoms than those whose mothers did not have these conditions (unadjusted OR 1.883, 95% CI 1.209-2.934; adjusted OR 1.943, 95% CI 1.236-3.054).Conclusions\n\nMothers who experience anxiety or depression during pregnancy may have a higher likelihood of their children developing ASD with GI symptoms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China, 86 0817 2262406, 86 0817-2262406.",
    "Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Boli Cheng",
      "orcid": "0009-0003-8105-9791"
    },
    {
      "affs": [
        1
      ],
      "name": "Enyu Wan",
      "orcid": "0009-0004-9638-9221"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuanxia He",
      "orcid": "0009-0005-5862-8882"
    },
    {
      "affs": [
        0
      ],
      "name": "Si Wang",
      "orcid": "0009-0005-7255-2861"
    },
    {
      "affs": [
        0
      ],
      "name": "Yun He",
      "orcid": "0009-0002-2534-438X"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaojiang Lyu",
      "orcid": "0000-0002-5296-4421"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1323d197j5jcw.bib",
  "cited_by": 0,
  "doi": "10.2196/90446",
  "fulltext_url": "https://europepmc.org/articles/PMC13716425",
  "id": "1323d197j5jcw",
  "issns": [
    "2561-6722"
  ],
  "landing_url": "https://europepmc.org/article/MED/42950347",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Anxiety and Stress Disorders"
    ],
    [
      "heading",
      "Autism Spectrum Disorder (ASD)"
    ],
    [
      "heading",
      "Caregiving and Parenting for Chronic Pediatric Diseases"
    ],
    [
      "heading",
      "Diagnostic Tools in Mental Health"
    ],
    [
      "heading",
      "Original Paper"
    ],
    [
      "heading",
      "Perinatal Depression; Postpartum Depression; PPD"
    ],
    [
      "heading",
      "Perinatal Education for Parents"
    ],
    [
      "lcc",
      "RJ1-570"
    ],
    [
      "openalex",
      "2805|Autism Spectrum Disorder Research"
    ]
  ],
  "openalex": "W7224085604",
  "pdf_url": "https://europepmc.org/articles/PMC13716425?pdf=render",
  "pmcid": "PMC13716425",
  "pmid": "42950347",
  "published": "2026-10-01",
  "publisher": "JMIR Publications Inc.",
  "ris": "https://research.draconitic.com/paper/1323d197j5jcw.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:33Z",
      "native_id": "MED:42950347",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42950347"
    },
    {
      "first_seen": "2026-11-01T12:23:25Z",
      "native_id": "PMC13716425",
      "source": "pmc",
      "url": "https://doi.org/10.2196/90446"
    },
    {
      "first_seen": "2026-11-05T14:21:13Z",
      "native_id": "c1dddf6bb7f340b49ab35ec9a24e37e7",
      "source": "doaj",
      "url": "https://doi.org/10.2196/90446"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Autism Spectrum Disorder Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "The Association Between Prenatal Anxiety and Depression and Autism Spectrum Disorder With Gastrointestinal Symptoms in Children: Case-Control Study.",
  "title_text": "The Association Between Prenatal Anxiety and Depression and Autism Spectrum Disorder With Gastrointestinal Symptoms in Children: Case-Control Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T14:20:42Z",
  "url": "https://research.draconitic.com/paper/1323d197j5jcw",
  "venue": "JMIR pediatrics and parenting",
  "versions": []
}