{
  "abstract": "Background: Clinical remission and endoscopic mucosal healing are the main treatment targets in patients with ulcerative colitis (UC). Recently, the concept of disease clearance has been proposed as a potential target in UC. Objective: We aimed to evaluate the impact of disease clearance on long-term outcomes in UC patients. Methods: A multicenter retrospective cohort study was conducted at the Humanitas Research Hospital-IRCCS (Italy) and at the Nancy University Hospital (France) between 2014 and 2021. Disease clearance in UC was defined as simultaneous clinical (partial-Mayo score ≤2), endoscopic (endoscopic-Mayo score = 0), and histological (Nancy index = 0) remission, and patients were monitored over a long-time follow-up (≥12 months), to compare the occurrence of negative outcomes. Results: A total of 494 patients with UC was included in the study (269, 54.4% males). Disease clearance was present in 109 patients (22.1%) at baseline. Median follow up was 24 months. Patients with disease clearance were associated to a significantly lower risk of UC-related hospitalization compared with the control group (5.5% vs. 23.1%; p < 0.001) at last observation. Similarly, a lower rate of surgeries was detected in patients with disease clearance at baseline compared with those without (1.8% vs. 10.9%; p = 0.003). The Kaplan Meier curves confirmed that patients with disease clearance at baseline had a lower risk of hospitalization (log-rank p < 0.0001) and surgery (log-rank p < 0.00095). Conclusion: In UC patients with early disease clearance are at significant lower risk for hospitalization and surgery. Disease clearance should be considered as a new composite outcome.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Ferdinando d'Amico"
    },
    {
      "name": "Gionata Fiorino"
    },
    {
      "name": "Virginia Solitano"
    },
    {
      "name": "Eugenia Massarini"
    },
    {
      "name": "Lucas Guillo"
    },
    {
      "name": "Mariangela Allocca"
    },
    {
      "name": "Federica Furfaro"
    },
    {
      "name": "Alessandra Zilli"
    },
    {
      "name": "Stefanos Bonovas"
    },
    {
      "name": "Fernando Magro"
    },
    {
      "name": "Laurent Peyrin-Biroulet"
    },
    {
      "name": "Silvio Danese"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/13jgsw2ewmd5j.bib",
  "cited_by": 42,
  "doi": "10.1002/ueg2.12288",
  "fulltext_url": null,
  "id": "13jgsw2ewmd5j",
  "issns": [
    "2050-6406",
    "2050-6414"
  ],
  "landing_url": "https://hal.univ-lorraine.fr/hal-04168260v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W4295900395",
  "pdf_url": "https://hal.univ-lorraine.fr/hal-04168260/document",
  "pmcid": null,
  "pmid": "36107109",
  "published": "2026-09-17",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/13jgsw2ewmd5j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "hal-04168260",
      "source": "hal",
      "url": "https://hal.univ-lorraine.fr/hal-04168260v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Ulcerative colitis: Impact of early disease clearance on long‐term outcomes ‐ A multicenter cohort study",
  "title_text": "Ulcerative colitis: Impact of early disease clearance on long‐term outcomes ‐ A multicenter cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/13jgsw2ewmd5j",
  "venue": "United European Gastroenterology Journal",
  "versions": []
}