{
  "abstract": "Polyglutamine (polyQ) diseases are the most common form of inheritable neurodegeneration. Neuronal protein aggregates strongly correlate with polyQ symptoms; pathways that protect against protein aggregation may help mitigate the symptoms of poly-Q or delay disease onset. We used a C. elegans polyQ model, exposed to a heat stressor, to test potential protective mechanisms: glucose and vitamin D₃ (VD₃) supplementation. Glucose enrichment further shortened post-heat stress lifespan, while VD₃ in moderate doses trended toward restoring polyQ post-stress lifespan back to wild-type levels. These results show effects of early-life interventions that could indicate aspects of polyQ pathogenesis mechanisms and treatment options.",
  "abstract_shown": true,
  "affiliations": [
    "Biology, University of Central Arkansas.",
    "Biology, University of Central Arkansas, Conway, AR, United States."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "London Blackwell"
    },
    {
      "affs": [
        0
      ],
      "name": "Joseph Sharp"
    },
    {
      "affs": [
        0
      ],
      "name": "Gisselle Hernandez"
    },
    {
      "affs": [
        1
      ],
      "name": "Mindy Farris"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/13nnryzqt3qvg.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002376",
  "fulltext_url": "https://europepmc.org/articles/PMC13695841",
  "id": "13nnryzqt3qvg",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928783",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Genetic Neurodegenerative Diseases"
    ]
  ],
  "openalex": "W7221329056",
  "pdf_url": "https://europepmc.org/articles/PMC13695841?pdf=render",
  "pmcid": "PMC13695841",
  "pmid": "42928783",
  "published": "2026-10-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/13nnryzqt3qvg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928783",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928783"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Genetic Neurodegenerative Diseases",
      "subfield": "neuroscience"
    }
  ],
  "title": "Effects of Glucose and Vitamin D ₃ on Heat Stress Resistance in a Caenorhabditis elegans Model of Polyglutamine Aggregation Disease.",
  "title_text": "Effects of Glucose and Vitamin D ₃ on Heat Stress Resistance in a Caenorhabditis elegans Model of Polyglutamine Aggregation Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/13nnryzqt3qvg",
  "venue": "MicroPublication biology",
  "versions": []
}