{
  "abstract": "Owing to continuous bacterial proliferation, a persistent inflammatory response, and impaired vascularization, infected skin wounds remain a major clinical challenge. Herein, we fabricated a multifunctional skin-repair material by incorporating ZIF-8@CuO nanoparticles and a collagen-binding vascular endothelial growth factor mimetic peptide (C-VEGFMP) into a gelatin methacryloyl (GelMA) hydrogel. The ZIF-8@CuO nanoparticles were prepared by controllably depositing copper oxide (CuO) onto the surface of zeolitic imidazolate framework-8 (ZIF-8). ZIF-8@CuO can endowed the hydrogel with potent antibacterial and anti-inflammatory activities, as well as efficient near-infrared (NIR) photothermal conversion capability. C-VEGFMP was constructed by introducing a collagen-binding sequence into the VEGFMP. This modified peptide can stably anchor to GelMA and maintain its bioactivity at the hydrogel-tissue interface. The resulting ZIF-8@CuO/C-VEGFMP hydrogel exhibited favorable cytocompatibility, broad-spectrum antibacterial activity and prominent pro-angiogenic performance. Upon NIR irradiation, the photothermal effect of ZIF-8@CuO can synergistically eradicate pathogenic bacteria, thereby enhancing photothermal therapeutic efficacy. In addition, the sustained presence of bioactive C-VEGFMP promoted epithelial regeneration, collagen deposition, and neovascularization in infected full-thickness wounds. Transcriptomic analysis indicated that treatment with ZIF-8@CuO/C-VEGFMP under NIR irradiation exerted anti-inflammatory, pro-angiogenic and tissue-repair effects mainly by upregulating thrombomodulin (THBD) and Ets proto-oncogene 2 (Ets2) genes. This study provides a multifunctional strategy that combines nanoparticle-mediated photothermal antibacterial effects with functionalized peptides, offering a promising therapeutic modality for the management of infected skin injuries.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedics, The Second Hospital of Jilin University Yatai Street 4026, Nanguan District Changchun 130022 Jilin Province China pansu@jlu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shengyang Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Renfeng Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Haorui Du"
    },
    {
      "affs": [
        0
      ],
      "name": "Hanwen Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Su Pan",
      "orcid": "0000-0002-7133-1777"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/14d8e5xcgm8hz.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06950a",
  "fulltext_url": "https://europepmc.org/articles/PMC13647587",
  "id": "14d8e5xcgm8hz",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42852251",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7220893845",
  "pdf_url": "https://europepmc.org/articles/PMC13647587?pdf=render",
  "pmcid": "PMC13647587",
  "pmid": "42852251",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/14d8e5xcgm8hz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42852251",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42852251"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "A multifunctional ZIF-8@CuO/collagen-binding peptide hydrogel for photothermal-enhanced antibacterial and infected skin wound management.",
  "title_text": "A multifunctional ZIF-8@CuO/collagen-binding peptide hydrogel for photothermal-enhanced antibacterial and infected skin wound management.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/14d8e5xcgm8hz",
  "venue": "RSC advances",
  "versions": []
}