{
  "abstract": "Psoriasis is a T‐cell‐mediated inflammatory disease amplified by metabolic stress. Acetyl‐CoA carboxylase 1 (ACC1)‐dependent fatty acid synthesis is required for IL‐17‐producing T cells. Here, we asked whether short‐term systemic administration of soraphen A (SorA), a dual ACC1/2 inhibitor, modulates imiquimod (IMQ)‐induced psoriasiform inflammation under normal diet (ND) and Western diet (WD) conditions. Female C57BL/6J mice were fed ND or WD for 12 weeks prior to daily intraperitoneal injections of SorA or vehicle for 10 days, followed by 5 days of topical IMQ to induce psoriasiform dermatitis. Disease severity was assessed by macroscopic, histological, transcriptional, and flow cytometric readouts. Prophylactic SorA administration had no measurable effect in ND‐fed mice. In WD‐fed mice, prophylactic SorA reduced erythema, back skin thickening, and epidermal hyperplasia, whereas scaling remained unchanged. Selected histological skin readouts were numerically lower, whereas the qPCR panel showed no statistically significant differences. In skin‐draining lymph nodes, IL‐17A+ CD4+ and CD8+ T‐cell frequencies and numbers were significantly reduced, whereas γδT17 cells did not differ significantly. Hepatic steatosis scores were unchanged, but hepatic neutrophil infiltration was reduced. Under the present prophylactic regimen, systemic SorA administration was associated with modest attenuation of WD‐exacerbated IMQ‐induced psoriasiform inflammation. These findings support further preclinical evaluation of ACC‐targeted immunometabolic interventions in metabolically aggravated psoriasiform inflammation.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany",
    "Division of Chronic Inflammation and Cancer German Cancer Research Center (DKFZ) Heidelberg Germany",
    "Department of Dermatology University Hospital Heidelberg Heidelberg Germany",
    "Fachbereich Biologie Johannes Gutenberg University Mainz Mainz Germany",
    "Institute of Molecular Medicine University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany",
    "Institute of Pathology University Hospital Heidelberg Heidelberg Germany",
    "Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) Saarland University Campus Saarbrücken Germany",
    "German Centre for Infection Research (DZIF) Partner Site Hannover‐Braunschweig Braunschweig Germany",
    "Department of Pharmacy Saarland University Saarbrücken Germany",
    "The M3 Research Center Institute For Interdisciplinary Research On Cancer Metabolism and Chronic Inflammation Eberhard Karls University Tübingen Medical Faculty Tübingen Germany",
    "Research Center for Immunotherapy (FZI) University Medical Center Johannes Gutenberg‐University Mainz Mainz Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu‐San Kao"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Katharina S. Kommoss"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Tabea Bieler"
    },
    {
      "affs": [
        4
      ],
      "name": "Gloria Janet Godoy"
    },
    {
      "affs": [
        0
      ],
      "name": "Aleksandra Lopez Krol"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatima Boukhallouk"
    },
    {
      "affs": [
        5
      ],
      "name": "Felix K. F. Kommoss"
    },
    {
      "affs": [
        1
      ],
      "name": "Danijela Heide"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Susanne H. Kirsch"
    },
    {
      "affs": [
        6,
        7,
        8
      ],
      "name": "Rolf Müller"
    },
    {
      "affs": [
        1,
        9
      ],
      "name": "Mathias Heikenwälder"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Tim Sparwasser"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/14e69ka9ckanr.bib",
  "cited_by": 0,
  "doi": "10.1002/eji.70298",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714554/",
  "id": "14e69ka9ckanr",
  "issns": [
    "0014-2980",
    "1521-4141"
  ],
  "landing_url": "https://doi.org/10.1002/eji.70298",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Allergy and Inflammation"
    ],
    [
      "heading",
      "Basic"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
    ]
  ],
  "openalex": "W7224091865",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.70298",
  "pmcid": "PMC13714554",
  "pmid": "42947523",
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/14e69ka9ckanr.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:01Z",
      "native_id": "PMC13714554",
      "source": "pmc",
      "url": "https://doi.org/10.1002/eji.70298"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Psoriasis: Treatment and Pathogenesis",
      "subfield": "immunology"
    }
  ],
  "title": "Prophylactic Soraphen A Treatment Attenuates Western Diet‐Exacerbated IMQ‐Induced Psoriasiform Inflammation",
  "title_text": "Prophylactic Soraphen A Treatment Attenuates Western Diet‐Exacerbated IMQ‐Induced Psoriasiform Inflammation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:01Z",
  "url": "https://research.draconitic.com/paper/14e69ka9ckanr",
  "venue": "European Journal of Immunology",
  "versions": []
}