{
  "abstract": "Objectives: RedLabRA is a network of microbiology laboratories for the genomic surveillance of antibiotic resistance. The aim of this study was to describe the actions undertaken by RedLabRA in response to an increase of vancomycin-resistant enterococci (VRE) in some Spanish regions.\n\nMethods: RedLabRA designed a VRE surveillance organized in two phases: (1) a questionnaire to assess risk perception of VRE among the network’s Level 2 laboratories (LN2), and (2) collection of cases detected between April 2023 and March 2024, followed by WGS of a sample of vancomycin-resistant Enterococcus faecium (VREfm) isolates to investigate interregional dissemination. WGS was performed using the Illumina platform; MLST ( PubMLST.org scheme), cgMLST and phylogenetic relationships (Ridom SeqSphere+ v3.5.0), and resistome (Resfinder 4.7.2) were analysed.\n\nResults: Nine of the 17 autonomous communities defined a priority scenario of VRE. 31 LN2 reported 1,958 VRE cases from 86 hospitals across 12 autonomous communities and the autonomous city Ceuta. The predominant species was E. faecium (97.1%). 317 VREfm isolates were included for WGS: 211 (66.6%) carried the van A gene, 90 (28.4%) van B, and 16 (5%) both genes. ST117 (34.7%), ST80 (27.1%), or ST1421 (25.6%) predominated. Using cgMLST (1,423 genes, cutoff of 5 alleles), 45 VREfm clusters were identified, of which eight involved at least three hospitals and were inter-regional. 51 (16.1%) isolates carried linezolid resistance mechanisms, mainly optr A+ cfr D.\n\nConclusion: VREfm had a highly uneven impact across Spanish regions. The inter-regional presence of VREfm isolates with high genetic similarity belonging to ST1421, ST117, and ST80 clones was detected. The emergence of E. faecium isolates carrying genes conferring resistance to vancomycin and linezolid requires ongoing surveillance.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III",
    "Laboratory Network for the Surveillance of Resistant Microorganisms (RedLabRA)",
    "CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III",
    "Servicio de Microbiología, Hospital Universitario de Guadalajara",
    "Servicio de Microbiología, Hospital Clínico Universitario de Valencia",
    "Complejo Asistencial Universitario de Burgos",
    "Servicio de Microbiología, Hospital General Universitario de Castellón",
    "Servicio de Microbiología, Hospital Universitario Río Hortega",
    "Servicio de Microbiología, Hospital Universitario 12 de Octubre",
    "Servicio de Microbiología, Hospital Universitario Ramón y Cajal",
    "Servicio de Microbiología, Hospital Universitario Vall d’Hebron",
    "Servicio de Microbiología, Hospital Universitario Gregorio Marañón",
    "Servicio de Microbiología, Hospital Clinic",
    "Servicio de Microbiología Clínica, Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet de Llobregat",
    "CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III",
    "Servicio de Microbiología, Hospital Universitario Nuestra Señora de Candelaria",
    "Servicio de Microbiología, Hospital Universitario Miguel Servet, IIS Aragón",
    "Servicio de Microbiología, Hospital Universitario Clínico San Carlos",
    "Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC)",
    "Servicio de Microbiología, Hospital Universitario Lozano Blesa",
    "Servicio de Microbiología, Hospital Universitario Virgen Macarena",
    "Servicio de Microbiología, Hospital Universitario La Paz",
    "Servicio de Microbiología, Hospital Universitario Santa Creu i Sant Pau",
    "Unidad Mixta de Investigación en Infección y Salud Pública, FISABIO, Universidad de Valencia - I2SysBio",
    "CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Javier E. Cañada-García"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Sara Pérez de Madrid"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Estela Giménez Quiles"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "María Pilar Ortega-Lafont"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "María Dolores Tirado-Balaguer"
    },
    {
      "affs": [
        1,
        7
      ],
      "name": "Luis López-Urrutia"
    },
    {
      "affs": [
        1,
        8
      ],
      "name": "Esther Viedma-Moreno"
    },
    {
      "affs": [
        1,
        2,
        9
      ],
      "name": "Marta Hernández-García"
    },
    {
      "affs": [
        1,
        2,
        10
      ],
      "name": "Nieves Larrosa-Escartín"
    },
    {
      "affs": [
        1,
        11
      ],
      "name": "Julia Serrano-Lobo"
    },
    {
      "affs": [
        1,
        2,
        12
      ],
      "name": "Ignasi Roca"
    },
    {
      "affs": [
        1,
        13,
        14
      ],
      "name": "Jordi Càmara"
    },
    {
      "affs": [
        1,
        15
      ],
      "name": "Diego García Martínez-de-Artola"
    },
    {
      "affs": [
        1,
        16
      ],
      "name": "Ana Isabel López-Calleja"
    },
    {
      "affs": [
        1,
        17,
        18
      ],
      "name": "Paloma Merino Amador"
    },
    {
      "affs": [
        1,
        2,
        19
      ],
      "name": "Cristina Seral"
    },
    {
      "affs": [
        1,
        2,
        20
      ],
      "name": "Lorena López-Cerero"
    },
    {
      "affs": [
        1,
        21
      ],
      "name": "Fernando Lázaro-Perona"
    },
    {
      "affs": [
        1,
        22
      ],
      "name": "Ferran Navarro"
    },
    {
      "affs": [
        1,
        23,
        24
      ],
      "name": "Fernando González-Candelas"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "María Pérez-Vázquez"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jesús Oteo-Iglesias"
    },
    {
      "name": "the Spanish RedLabRA Network Study Group"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/14jwq2dkxjw2a.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1966902",
  "fulltext_url": null,
  "id": "14jwq2dkxjw2a",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1966902/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/14jwq2dkxjw2a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:24Z",
      "native_id": "10.3389/fpubh.2026.1966902",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1966902/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2296-2565",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Vancomycin-resistant enterococci in Spanish hospitals: the experience of official network for the surveillance of resistant microorganisms RedLabRA, 2023–2024",
  "title_text": "Vancomycin-resistant enterococci in Spanish hospitals: the experience of official network for the surveillance of resistant microorganisms RedLabRA, 2023–2024",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:21:09Z",
  "url": "https://research.draconitic.com/paper/14jwq2dkxjw2a",
  "venue": "Frontiers in Public Health",
  "versions": []
}