{ "abstract": "Introduction: The first‐trimester combined screening test for preterm preeclampsia (preterm‐PE) has been implemented in Mainland China. This study aims, first, to evaluate the applicability of multiple of the median (MoM) models based on biomarkers developed and utilized in a European population for prospective preterm‐PE screening in Mainland China; second, to assess the criteria for biomarker adjustment; and third, to establish criteria for continuous quality assurance in the screening process.\n\nMaterial and Methods: In this prospective multicenter cross‐sectional study, 22 066 singleton pregnancies undergoing preterm‐PE screening at 11 + 0–13 + 6 weeks were recruited from six tertiary hospitals in Mainland China. Mean arterial pressure (MAP) and placental growth factor (PlGF) were measured and converted to their equivalent MoM values using Fetal Medicine Foundation MoMing models incorporated in commercial software. PlGF levels were also determined using immunoassays developed in China. MoM and log10MoM distributions in the initial screened subjects were assessed for (1) central tendency and dispersion and (2) whether biomarker MoM distributions needed to be recentered. Biomarker central tendency and temporal stability both before and after recentering were assessed using Cumulative Sum plots. Distribution central tendency was considered good if its median MoM was between 0.95 and 1.05 and acceptable if between 1.05 and 1.10.\n\nResults: After excluding the initial 400 pregnancies from each center, all PlGF, but not all MAP MoM distributions, required recentering. Post‐recentering, the overall distribution median (95% confidence interval) MoM values for MAP and PlGF were 1.003 (1.001, 1.004) and 1.004 (0.996, 1.013), respectively.\n\nConclusions: Chinese centers performing combined PE screening should assess biomarker MoM distributions in their initial cases to ensure that they conform to the expected central tendencies assumed in the risk estimation models.", "abstract_shown": true, "affiliations": [ "Department of Reproductive Center, National Clinical Research Center for Chinese Medicine First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China", "Department of Obstetrics and Gynaecology Prince of Wales Hospital, The Chinese University of Hong Kong Hong Kong SAR China", "Department of Obstetrics Obstetrics and Gynaecology Hospital of Fudan University Shanghai China", "Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University Shenzhen Guangdong Province China", "Department of Obstetrics and Gynaecology and Reproductive Medicine Peking University First Hospital Beijing China", "Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal‐Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University Shanghai China", "Department of Obstetrics and Gynaecology West China Second University Hospital, Sichuan University Chengdu China", "Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Ministry of Education Chengdu Sichuan China", "Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region Nanning Guangxi P. R. China", "Shenzhen Research Institute, The Chinese University of Hong Kong Hong Kong SAR China", "Fetal Medicine Center Tam Anh General Hospital Ho Chi Minh City Vietnam" ], "article_type": "research article", "arxiv": null, "author_total": 17, "authors": [ { "affs": [ 0, 1 ], "name": "Jiao Liu", "orcid": "0009-0003-0508-7678" }, { "affs": [ 2, 3 ], "name": "Xiaotian Li", "orcid": "0000-0002-2051-4581" }, { "affs": [ 4 ], "name": "Huixia Yang" }, { "affs": [ 2 ], "name": "Qiongjie Zhou", "orcid": "0000-0002-1264-161X" }, { "affs": [ 5 ], "name": "Hao Ying" }, { "affs": [ 6, 7 ], "name": "Rong Zhou" }, { "affs": [ 6, 7 ], "name": "Yanping Zhang" }, { "affs": [ 4 ], "name": "Wang Xueyin", "orcid": "0000-0003-4461-324X" }, { "affs": [ 5 ], "name": "Han Xie" }, { "affs": [ 3 ], "name": "Xinzhi Tu" }, { "affs": [ 8 ], "name": "Lin Kong" }, { "affs": [ 8 ], "name": "Jie Qin" }, { "affs": [ 1, 9 ], "name": "Chi Chiu Wang", "orcid": "0000-0002-3928-7278" }, { "affs": [ 1 ], "name": "Xiaohong Lu" }, { "affs": [ 1, 10 ], "name": "Long Nguyen‐Hoang" }, { "affs": [ 1, 9 ], "name": "Daljit S. Sahota" }, { "affs": [ 1, 9 ], "name": "Liona C. Poon", "orcid": "0000-0002-3944-4130" } ], "bibtex": "https://research.draconitic.com/paper/14nrjc326pf0c.bib", "cited_by": 0, "doi": "10.1111/aogs.70319", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13394656/", "id": "14nrjc326pf0c", "issns": [ "0001-6349", "1600-0412" ], "landing_url": "https://doi.org/10.1111/aogs.70319", "language": "en", "licence": "CC-BY-NC-4.0", "licence_label": "CC BY-NC 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Original Research" ], [ "heading", "Pregnancy" ], [ "openalex", "2729|Pregnancy and preeclampsia studies" ] ], "openalex": "W7168375026", "pdf_url": null, "pmcid": "PMC13394656", "pmid": "42452901", "published": "2026-07-14", "publisher": "Wiley", "ris": "https://research.draconitic.com/paper/14nrjc326pf0c.ris", "sources": [ { "first_seen": "2026-10-30T12:17:28Z", "native_id": "PMC13394656", "source": "pmc", "url": "https://doi.org/10.1111/aogs.70319" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2729|Pregnancy and preeclampsia studies", "subfield": "reproductive-child" } ], "title": "Assessing quality standards of biomarker measurement in first‐trimester combined screening for preeclampsia in the Chinese population: A multicenter study", "title_text": "Assessing quality standards of biomarker measurement in first‐trimester combined screening for preeclampsia in the Chinese population: A multicenter study", "type": "peer-reviewed", "updated_at": "2026-10-30T12:33:27Z", "url": "https://research.draconitic.com/paper/14nrjc326pf0c", "venue": "Acta Obstetricia et Gynecologica Scandinavica", "versions": [] }