{
  "abstract": "Background/Objectives: Cervical cancer prevention relies on cytology, high-risk human papillomavirus (HR-HPV) testing, and histological confirmation, but these modalities may disagree. We quantified test concordance and determinants of CIN2+ in a specialized gynecologic referral cohort with very low HPV vaccination coverage. Methods: We retrospectively analyzed 172 women evaluated for suspected or established cervical pathology between 2022 and 2024. Of these, 160 had a definitive HPV result and 130 had histology; histology-based performance analyses used complete cases and are conditional on biopsy verification. Cytology was categorized by the Bethesda system, HR-HPV genotypes were recorded, and histology was dichotomized as CIN2+ versus ≤CIN1. Results: Among 160 women with definitive HPV results, 109 (68.1%) were HPV-positive. HPV-positive women were younger (median 33 vs. 43 years, p < 0.001) and, among biopsied women, more frequently had CIN2+ (70.2% vs. 22.2%, p < 0.001). Cyto-histological agreement was fair (65.0%, κ = 0.32). HPV16/18 was strongly associated with CIN2+ (OR 6.85, 95% CI 2.54-18.49). Within histologically verified complete cases, HPV DNA positivity had the highest apparent sensitivity (91.7%), whereas HPV16/18 had the highest PPV (86.0%). Conclusions: Cytology and HR-HPV testing provide complementary information in this referral-enriched cohort. Because disease prevalence was high and biopsy verification was selective, predictive values and apparent diagnostic-performance estimates should not be extrapolated directly to population screening; external validation in primary-screening populations is required.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral School of Medicine, Faculty of Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.",
    "Department I of Anatomy and Embryology, Faculty of Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.",
    "Department of Clinical Practical Skills, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.",
    "Department XII, Obstetrics-Gynecology I, Faculty of Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maria-Daniela Vasieș Mazilu"
    },
    {
      "affs": [
        0
      ],
      "name": "Elena-Lavinia Rusu",
      "orcid": "0009-0006-1607-8496"
    },
    {
      "affs": [
        0
      ],
      "name": "Jasmina-Sorina Chiriac"
    },
    {
      "affs": [
        1
      ],
      "name": "Alexandra-Corina Faur"
    },
    {
      "affs": [
        2
      ],
      "name": "Elena-Rodica Heredea"
    },
    {
      "affs": [
        3
      ],
      "name": "Veronica-Daniela Chiriac"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/158qhk9fnqgpm.bib",
  "cited_by": 0,
  "doi": "10.3390/diagnostics16193204",
  "fulltext_url": "https://europepmc.org/articles/PMC13664056",
  "id": "158qhk9fnqgpm",
  "issns": [
    "2075-4418"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882358",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Cervical Cancer and HPV Research"
    ]
  ],
  "openalex": "W7216366503",
  "pdf_url": "https://europepmc.org/articles/PMC13664056?pdf=render",
  "pmcid": "PMC13664056",
  "pmid": "42882358",
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/158qhk9fnqgpm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42882358",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882358"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Cervical Cancer and HPV Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Cytology, High-Risk HPV Genotyping, and Histology in Cervical Pathology: A Retrospective Cohort Study.",
  "title_text": "Cytology, High-Risk HPV Genotyping, and Histology in Cervical Pathology: A Retrospective Cohort Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/158qhk9fnqgpm",
  "venue": "Diagnostics (Basel, Switzerland)",
  "versions": []
}