{
  "abstract": "High-dose EGFR-TKIs have been used as an exploratory therapeutic strategy to overcome the limitations of the standard-dose regimen in the treatment of EGFR-mutant NSCLC, particularly in patients with CNS metastases. Available clinical evidence suggests that high-dose TKIs confer certain therapeutic efficacy and manageable safety profiles, with a small proportion of patients experiencing ≥3 grade adverse events, such as rash, nausea,diarrhea, aminotransferase rise, leukopenia.However, the evidence is limited by the predominance of single-center retrospective studies, small sample sizes, heterogeneous patient populations and short follow-up periods. Further large-scale, multicenter studies with long-term follow-up are needed to define more clearly the efficacy, safety, and appropriate clinical role of high-dose EGFR-TKI therapy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Kai Cheng"
    },
    {
      "name": "Yan Chen"
    },
    {
      "name": "Xiaowen Tao"
    },
    {
      "name": "HongTao Xiao"
    },
    {
      "name": "Hua Xie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/158xjcrtbccce.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1903921",
  "fulltext_url": null,
  "id": "158xjcrtbccce",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1903921",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/pharmacology-toxicology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/158xjcrtbccce.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:33Z",
      "native_id": "10.3389/fphar.2026.1903921",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1903921"
    },
    {
      "first_seen": "2026-11-09T12:23:31Z",
      "native_id": "10.3389/fphar.2026.1903921",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1903921/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/pharmacology-toxicology",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "High-dose administration of EGFR-TKIs for NSCLC patients: a literature review",
  "title_text": "High-dose administration of EGFR-TKIs for NSCLC patients: a literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/158xjcrtbccce",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}