{
  "abstract": "Alzheimer's disease (AD) remains a major cause of cognitive decline and societal burden. The recent approval of disease-modifying therapies (DMTs) lecanemab and donanemab represents a paradigm shift in AD treatment. We assessed the preparedness of Portuguese centers to implement DMTs. A nationwide survey-based cross-sectional service-capacity study targeted memory clinics, focusing primarily on National Health System (NHS) centers. Data were collected on clinical capacity, diagnostic access, treatment capability, and research activity. Among 51 responding units, 20 had organized memory clinics (17 in the NHS), covering 60.7% of the population. In 2024, these centers conducted 21,721 consultations, representing expert care for <10% of the total AD patients estimated to exist in Portugal. Bottlenecks included long waiting times and limited biomarker access (26.2% underwent cerebrospinal fluid or amyloid positron emission tomography). Nationwide, from experts' estimates, 701 patients could currently start treatment. Portugal's current NHS capacity appears insufficient for broad DMT implementation, requiring major investment in diagnostics, training, infrastructure, and research to ensure equitable and effective treatment access.",
  "abstract_shown": true,
  "affiliations": [
    "Clinical Academic Center of Coimbra (CACC) Faculty of Medicine University of Coimbra Coimbra Portugal.",
    "Neurology Department Centro Hospitalar e Universitário de Coimbra Coimbra Portugal.",
    "Centre for Innovative Biomedicine and Biotechnology (CIBB) Universidade de Coimbra Coimbra Portugal.",
    "Centre for Informatics and Systems Department of Informatics Engineering University of Coimbra Coimbra Portugal.",
    "Neurology Department ULS Alto Alentejo Portalegre Portugal.",
    "NOVA Medical School | Faculdade de Ciências Médicas Universidade Nova de Lisboa Lisboa Portugal.",
    "Hospital de Egas Moniz Unidade Local de Saúde de Lisboa Ocidental Lisboa Portugal.",
    "Centro Clínico e Académico de Lisboa Lisboa Portugal.",
    "Memory Unit CUF Porto Porto Portugal.",
    "Department of Clinical Neurosciences and Mental Health Faculty of Medicine University of Porto Porto Portugal.",
    "Neurology Department ULS Alto Ave Guimarães Portugal.",
    "Life and Health Sciences Research Institute (ICVS) School of Medicine Campus Gualtar University of Minho Braga Portugal.",
    "Neurology Department ULS Gaia/Espinho Vila Nova de Gaia Portugal.",
    "Neurology Department Unidade Local de Saúde do Alentejo Central Évora Portugal.",
    "Department of Neurology Hospital Universitário São João Porto Portugal.",
    "Neurology Department ULS Estuário do Tejo Vila Franca de Xira Portugal.",
    "Neurology Department Unidade Local de Saúde da Guarda Guarda Portugal.",
    "Neurology Department ULS Algarve Faro Portugal.",
    "Neurology Department Hospital Dr. Nélio Mendonça Funchal Portugal.",
    "Laboratory of Clinical Pharmacology and Therapeutics Faculdade de Medicina Universidade Lisboa Lisbon Portugal.",
    "CNS - Campus Neurológico Torres Vedras Portugal.",
    "Neurology Department ULS Arco Ribeirinho Barreiro-Montijo Barreiro Portugal.",
    "Neurology Department ULS Almada-Seixal Almada Portugal.",
    "Neurology Department Local Health Unit of the Leiria Region Leiria Portugal.",
    "Department of Neurology Centro Hospitalar Universitário de Santo António Porto Portugal.",
    "Neurology department ULS Cova da Beira Covilhã Portugal.",
    "Neurology department ULS Região de Aveiro Aveiro Portugal.",
    "Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR)| Coimbra Institute for Clinical and Biomedical Research (iCBR) Coimbra Portugal.",
    "Neurology Department Hospital Professor Doutor Fernando Fonseca Lisboa Portugal.",
    "Unit of Multidisciplinary Research in Biomedicine (UMIB) ICBAS School of Medicine and Biomedical Sciences University of Porto Porto Portugal.",
    "i3S - Instituto de Investigação e Inovação em Saúde University of Porto Porto Portugal.",
    "Neurology Department ULS Braga Braga Portugal.",
    "Faculty of Medicine University of Lisbon Lisbon Portugal.",
    "Department of Neurosciences and Mental Health ULS Santa Maria Lisbon Portugal.",
    "Champalimaud Research Champalimaud Foundation Lisbon Portugal.",
    "Hospital da Cruz Vermelha Lisbon Portugal.",
    "Neurology Department Hospital de Cascais Dr. José de Almeida Cascais Portugal.",
    "Neurology Department ULS Loures Odivelas Lisbon Portugal.",
    "Neurology Department ULS São José Lisbon Portugal.",
    "Neurology Department ULS de Entre o Douro e Vouga Santa Maria da Feira Portugal."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 53,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Miguel Tábuas-Pereira",
      "orcid": "0000-0002-3988-614X"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Anuschka Silva-Spínola"
    },
    {
      "affs": [
        4
      ],
      "name": "Catarina Agostinho"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Luísa Alves"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Rui Araújo"
    },
    {
      "affs": [
        0,
        1,
        10,
        11
      ],
      "name": "Catarina Bernardes"
    },
    {
      "affs": [
        12
      ],
      "name": "Mariana Branco"
    },
    {
      "affs": [
        13
      ],
      "name": "Cláudia Borbinha"
    },
    {
      "affs": [
        9,
        14
      ],
      "name": "Verónica Cabreira"
    },
    {
      "affs": [
        15
      ],
      "name": "Sónia Costa"
    },
    {
      "affs": [
        16
      ],
      "name": "Alexandra Dias Silva"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "João Durães"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Pedro Faustino"
    },
    {
      "affs": [
        17
      ],
      "name": "Catarina Félix"
    },
    {
      "affs": [
        18
      ],
      "name": "Andreia Fernandes"
    },
    {
      "affs": [
        19,
        20
      ],
      "name": "Joaquim Ferreira"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Miguel Gago"
    },
    {
      "affs": [
        21
      ],
      "name": "Cláudia Guarda"
    },
    {
      "affs": [
        22
      ],
      "name": "Cristina Ionel"
    },
    {
      "affs": [
        23
      ],
      "name": "Joana Jesus-Ribeiro"
    },
    {
      "affs": [
        24
      ],
      "name": "Inês Laranjinha"
    },
    {
      "affs": [
        25
      ],
      "name": "André Leitão"
    },
    {
      "affs": [
        26,
        27
      ],
      "name": "Liliana Letra"
    },
    {
      "affs": [
        28
      ],
      "name": "Pedro Lopes das Neves"
    },
    {
      "affs": [
        24,
        29,
        30
      ],
      "name": "Luis F Maia"
    },
    {
      "affs": [
        9,
        31
      ],
      "name": "Álvaro Machado"
    },
    {
      "affs": [
        8,
        9,
        14
      ],
      "name": "Bárbara Martins"
    },
    {
      "affs": [
        9,
        14
      ],
      "name": "João Massano"
    },
    {
      "affs": [
        32,
        33
      ],
      "name": "Alexandre Mendonça"
    },
    {
      "affs": [
        5,
        34
      ],
      "name": "Marcelo Mendonça"
    },
    {
      "affs": [
        35
      ],
      "name": "Rita Miguel"
    },
    {
      "affs": [
        36
      ],
      "name": "Miguel Miranda"
    },
    {
      "affs": [
        20,
        37
      ],
      "name": "Joana Morgado"
    },
    {
      "affs": [
        20,
        38
      ],
      "name": "Camila Nóbrega"
    },
    {
      "affs": [
        38
      ],
      "name": "Maria Pereira Coutinho"
    },
    {
      "affs": [
        38
      ],
      "name": "Tiago Oliveira"
    },
    {
      "affs": [
        36
      ],
      "name": "Fernando Pita"
    },
    {
      "affs": [
        12
      ],
      "name": "Francisco Sabença"
    },
    {
      "affs": [
        9,
        31
      ],
      "name": "Sofia Rocha"
    },
    {
      "affs": [
        39
      ],
      "name": "Luis Ruano"
    },
    {
      "name": "Telma Santos"
    },
    {
      "name": "Frederico Simões do Couto"
    },
    {
      "affs": [
        29
      ],
      "name": "Ricardo Taipa"
    },
    {
      "name": "Vitor Tedim Cruz"
    },
    {
      "affs": [
        5
      ],
      "name": "Ana H Valverde"
    },
    {
      "name": "Ana Vélon"
    },
    {
      "affs": [
        32,
        33
      ],
      "name": "Ana Verdelho"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Miguel Viana Baptista"
    },
    {
      "name": "Daniela Vieira"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Marisa Lima"
    },
    {
      "affs": [
        11
      ],
      "name": "Tiago Gil Oliveira"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Isabel Santana"
    },
    {
      "name": "Scientific Alliance of Units Dedicated to Alzheimer's Disease (SAUDAD) consortium"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/160yrz9dmbcgx.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70513",
  "fulltext_url": "https://europepmc.org/articles/PMC13715078",
  "id": "160yrz9dmbcgx",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953259",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7224092790",
  "pdf_url": "https://europepmc.org/articles/PMC13715078?pdf=render",
  "pmcid": "PMC13715078",
  "pmid": "42953259",
  "published": "2026-10-28",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/160yrz9dmbcgx.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:40Z",
      "native_id": "MED:42953259",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953259"
    },
    {
      "first_seen": "2026-11-01T12:22:27Z",
      "native_id": "PMC13715078",
      "source": "pmc",
      "url": "https://doi.org/10.1002/dad2.70513"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Current capacity of Portuguese specialized dementia centers in the era of anti-amyloid antibodies.",
  "title_text": "Current capacity of Portuguese specialized dementia centers in the era of anti-amyloid antibodies.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:27Z",
  "url": "https://research.draconitic.com/paper/160yrz9dmbcgx",
  "venue": "Alzheimer's & dementia (Amsterdam, Netherlands)",
  "versions": []
}