{
  "abstract": "Endometrial decidualization is a hormonally programmed differentiation and tissue-remodeling process that prepares the endometrium for embryo implantation and supports early pregnancy. It involves coordinated changes in endometrial stromal cells, the extracellular matrix, vascular function, metabolism, and local immune composition. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor that responds to changes in tissue oxygenation and metabolic state. Evidence from endometrial stromal-cell models and reproductive tissues suggests that HIF-1α may participate in decidual cell differentiation, metabolic adaptation, angiogenic signaling, and immune regulation. However, the strength of evidence differs substantially among these processes, and findings from trophoblasts, placenta, immune cells, or non-reproductive tissues cannot automatically be interpreted as direct evidence for decidual stromal-cell mechanisms. This review summarizes current evidence for HIF-1α in endometrial decidualization, distinguishes direct endometrial findings from mechanistic extrapolation, and considers the interaction of HIF-1α with metabolic, vascular, immune, and epigenetic pathways. Overall, HIF-1α is best considered a context-dependent component of the decidualization network rather than an independent master regulator. Defining its cell-specific and temporal functions, including its relationship with HIF-2α, will be important for determining whether HIF-directed interventions can be developed without disrupting physiological reproductive adaptation.",
  "abstract_shown": true,
  "affiliations": [
    "Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen 361102, China",
    "Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China",
    "Fujian Key Laboratory of Integrative Medicine on Geriatrics, College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Defan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenghong Zhang",
      "orcid": "0000-0003-4309-0221"
    },
    {
      "affs": [
        2
      ],
      "name": "Renfeng Xu",
      "orcid": "0000-0002-1487-6308"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhengchao Wang",
      "orcid": "0000-0001-7439-9630"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/162ke9rbx5z2z.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16101483",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702554/?tool=EBI",
  "id": "162ke9rbx5z2z",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/10/1483",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Reproductive System and Pregnancy"
    ]
  ],
  "openalex": "W7221707329",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702554/pdf/?tool=EBI",
  "pmcid": "PMC13702554",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/162ke9rbx5z2z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16101483",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/10/1483"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13702554",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702554"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Reproductive System and Pregnancy",
      "subfield": "immunology"
    }
  ],
  "title": "Role of Hypoxia-Inducible Factor-1 Alpha in Endometrial Decidualization",
  "title_text": "Role of Hypoxia-Inducible Factor-1 Alpha in Endometrial Decidualization",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:25Z",
  "url": "https://research.draconitic.com/paper/162ke9rbx5z2z",
  "venue": "Biomolecules",
  "versions": []
}