{
  "abstract": "Cellular quiescence is a low metabolic, non-proliferative state critical for tissue maintenance and regenerative capacity, with broad implications for aging and age-related diseases. In Caenorhabditis elegans, L1 developmental arrest upon hatching in the absence of food provides a robust in vivo model to study quiescence. Here, we investigate the roles of the transcription factors HLH-30/TFEB and DAF-16/FOXO during L1 arrest. We show that HLH-30 and DAF-16 collaborate to ensure survival under starvation, with reciprocal regulation of their subcellular localization and transcriptional activity. HLH-30 exerts broad transcriptional control during L1 arrest, modulating genes involved in chromosome organization and cell cycle progression. Profiling of chromatin spatial distribution reveals that HLH-30 is required for fasting-induced 3D chromatin reorganization. Loss of HLH-30 disrupts seam cell cycle arrest and causes the overactivation of the transcription factors BLMP-1 and CEBP-1, which contribute to premature initiation of developmental programs under starvation. Our findings uncover previously unrecognized functions of HLH-30 in genome architecture and quiescence regulation, highlighting conserved mechanisms of transcriptional control during nutrient deprivation with implications for aging and disease.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville 41012, Spain.",
    "Institute of Functional Epigenetics, Helmholtz Zentrum Muenchen, Neuherberg D-85764, Germany.",
    "Faculty of Medicine, Ludwig-Maximilians-Universität Muenchen, Munich D-80539, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marta Muñoz-Barrera"
    },
    {
      "affs": [
        0
      ],
      "name": "Alejandro Mata-Cabana",
      "orcid": "0000-0002-0179-2746"
    },
    {
      "affs": [
        0
      ],
      "name": "Almudena Moreno-Rivero"
    },
    {
      "affs": [
        0
      ],
      "name": "Francine A Piubeli",
      "orcid": "0000-0002-5065-5297"
    },
    {
      "affs": [
        0
      ],
      "name": "Beatriz Ren-Barroso",
      "orcid": "0009-0005-6817-7616"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Nada Al-Refaie"
    },
    {
      "affs": [
        0
      ],
      "name": "Gabriel Gutierrez"
    },
    {
      "affs": [
        1
      ],
      "name": "Daphne S Cabianca",
      "orcid": "0000-0002-1834-7868"
    },
    {
      "affs": [
        0
      ],
      "name": "María Olmedo",
      "orcid": "0000-0002-5701-2665"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/167p0gb34g9te.bib",
  "cited_by": 1,
  "doi": "10.1093/nar/gkag949",
  "fulltext_url": "https://europepmc.org/articles/PMC13646826",
  "id": "167p0gb34g9te",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://europepmc.org/article/MED/42847247",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7220983555",
  "pdf_url": "https://europepmc.org/articles/PMC13646826?pdf=render",
  "pmcid": "PMC13646826",
  "pmid": "42847247",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/167p0gb34g9te.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42847247",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42847247"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans.",
  "title_text": "HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/167p0gb34g9te",
  "venue": "Nucleic acids research",
  "versions": []
}