{
  "abstract": "We describe the case of a 57-year-old female with chronic hoarseness and cough whose laryngeal exam revealed chronic laryngitis with exudates. She failed multiple courses of fluconazole for presumed laryngeal candidiasis. Pathology demonstrated laryngeal cryptococcosis, and sputum cultures grew Cryptococcus neoformans with an elevated fluconazole MIC. Immunological evaluation led to the diagnosis of common variable immunodeficiency. After complications with alternative antifungals, the patient responded favorably to isavuconazole and intravenous immunoglobulin replacement.",
  "abstract_shown": true,
  "affiliations": [
    "Henry Ford Hospital, Division of Infectious Diseases, 2799 W Grand Blv, Detroit, MI, 48322, USA",
    "Henry Ford Hospital, Department of Otolaryngology, 2799 W Grand Blv, Detroit, MI, 48322, USA",
    "Henry Ford Hospital, Division of Infectious Diseases, 2799 W Grand Blv, Detroit, MI, 48322, USA; Corresponding author. 2799 W Grand Blvd, CFP-322, Detroit, MI, 48202, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rija Binte Rehan Alvi"
    },
    {
      "affs": [
        1
      ],
      "name": "Ross M. Mayerhoff"
    },
    {
      "affs": [
        2
      ],
      "name": "Eloy E. Ordaya"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/16egnqv6j81ws.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mmcr.2026.100831",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2211753926000734",
  "id": "16egnqv6j81ws",
  "issns": [
    "2211-7539"
  ],
  "landing_url": "https://doi.org/10.1016/j.mmcr.2026.100831",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2713|Fungal Infections and Studies"
    ]
  ],
  "openalex": "W7223684407",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/16egnqv6j81ws.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:26Z",
      "native_id": "0810eff392f94350896be33537237be4",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.mmcr.2026.100831"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Fungal Infections and Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Laryngeal cryptococcosis with clinical failure to fluconazole in a patient with common variable immunodeficiency: A treatment dilemma",
  "title_text": "Laryngeal cryptococcosis with clinical failure to fluconazole in a patient with common variable immunodeficiency: A treatment dilemma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:26Z",
  "url": "https://research.draconitic.com/paper/16egnqv6j81ws",
  "venue": "Medical Mycology Case Reports",
  "versions": []
}