{
  "abstract": "Atherosclerosis is driven by the persistent crosstalk among chronic inflammation, oxidative stress, and lipid dysmetabolism, largely orchestrated by plaque‐resident macrophages. However, therapeutic strategies capable of simultaneously modulating these interconnected pathological processes are still limited. Herein, we developed a hyaluronic acid‐coated, copper‐doped Prussian blue nanozyme (CuPB@HA) as a CD44‐associated plaque‐targeted nanotherapeutic. Guided by transcriptomic evidence of CD44 enrichment in atherosclerotic plaque macrophages, HA was incorporated to enhance lesion targeting and cellular internalization. In ox‐LDL‐stimulated macrophages, CuPB@HA effectively alleviated oxidative stress, suppressed inflammation, and attenuated lipid accumulation. Mechanistically, it reduced CD36‐dependent lipid uptake and increased the expression of cholesterol‐efflux‐related transporters ABCA1 and ABCG1, thereby shifting macrophages away from a pro‐inflammatory phenotype. In vivo, CuPB@HA preferentially accumulated within atherosclerotic lesions of ApoE−/− mice, significantly reducing plaque burden and improving plaque stability‐associated histological features. Collectively, CuPB@HA integrates redox regulation, macrophage lipid‐handling modulation, and inflammation attenuation, highlighting its potential as a targeted therapeutic strategy for atherosclerosis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital Shanghai People's Republic of China",
    "Department of Anesthesiology Changzheng Hospital Naval Medical University Shanghai People's Republic of China",
    "College of Chemistry and Materials Science Shanghai Normal University Shanghai People's Republic of China",
    "Wuhan United Imaging Life Science Instruments Ltd. Wuhan People's Republic of China",
    "Faculty of Medical Imaging Technology College of Health Science and Technology Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China",
    "Shanghai Normal University College of Life Science Shanghai People's Republic of China",
    "Key Laboratory of Multi‐Cell Systems Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Center for Excellence in Molecular Cell Science University of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai People's Republic of China",
    "Department of Pharmacy School of Medicine Renji Hospital Shanghai Jiao Tong University Shanghai People's Republic of China",
    "Department of Ultrasound in Medicine Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital Shanghai People's Republic of China",
    "Department of Nutrition and Food Hygiene School of Public Health Southeast University Nanjing People's Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jianliang Ou"
    },
    {
      "affs": [
        1
      ],
      "name": "Ruihua Ji"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Qinglu Zang"
    },
    {
      "affs": [
        3
      ],
      "name": "Mingkang Wang"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Lingling Zhou"
    },
    {
      "affs": [
        5
      ],
      "name": "Yingliang Wei"
    },
    {
      "affs": [
        6
      ],
      "name": "Di Yang"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Yue Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongxu Zhu"
    },
    {
      "affs": [
        8
      ],
      "name": "Jianrong Wu"
    },
    {
      "affs": [
        8
      ],
      "name": "Xiaojun Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenxian Du"
    },
    {
      "affs": [
        9
      ],
      "name": "Junjie Cheng",
      "orcid": "0000-0003-0502-6712"
    },
    {
      "affs": [
        6
      ],
      "name": "An Zeng",
      "orcid": "0000-0003-3011-5709"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuehua Li",
      "orcid": "0000-0003-2417-0867"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/16vbnfsh9kxf2.bib",
  "cited_by": 1,
  "doi": "10.1002/advs.76976",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13440190/",
  "id": "16vbnfsh9kxf2",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://doi.org/10.1002/advs.76976",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2505|Advanced Nanomaterials in Catalysis"
    ]
  ],
  "openalex": "W7172520065",
  "pdf_url": null,
  "pmcid": "PMC13440190",
  "pmid": "42554503",
  "published": "2026-08-05",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/16vbnfsh9kxf2.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:41Z",
      "native_id": "PMC13440190",
      "source": "pmc",
      "url": "https://doi.org/10.1002/advs.76976"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Advanced Nanomaterials in Catalysis",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy",
  "title_text": "Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:48Z",
  "url": "https://research.draconitic.com/paper/16vbnfsh9kxf2",
  "venue": "Advanced Science",
  "versions": []
}