{
  "abstract": "SignificanceIntracellular microorganisms are often confined to specialized host cells called bacteriocytes in invertebrates. Transcription factors play key roles in regulating bacteriocyte development, but underlying molecular mechanisms remain unclear. Our previous work demonstrates that the transcription factor Adf-1 suppresses cell death of whitefly bacteriocytes. Here, we unravel that Adf-1 induces the expression of the ataxia telangiectasia and Rad3-related (ATR ) gene in whitefly bacteriocytes. ATR negatively regulates DNA damage levels, apoptosis and autophagy of bacteriocytes, but positively regulates division and numbers of bacteriocytes. Thus, we identify a previously uncharacterized Adf-1-ATR regulatory pathway that safeguards whitefly bacteriocyte development and symbiosis by mitigating DNA damage. It highlights that DNA damage repair is indispensable for the functioning of evolutionarily novel cells like bacteriocytes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Na-Na Li"
    },
    {
      "name": "Shan Jiang"
    },
    {
      "name": "Ji-Sheng Hong"
    },
    {
      "name": "Federica Calevro"
    },
    {
      "name": "Kai-Heng Wei"
    },
    {
      "name": "Kun-Yu Lu"
    },
    {
      "name": "Jun-Bo Luan"
    },
    {
      "name": "Joan E Strassmann"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/16wxgtmervqp3.bib",
  "cited_by": 0,
  "doi": "10.1073/pnas.26183101231of10",
  "fulltext_url": null,
  "id": "16wxgtmervqp3",
  "issns": [
    "0027-8424",
    "1091-6490"
  ],
  "landing_url": "https://hal.science/hal-05780619v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ee"
    ],
    [
      "hal",
      "2.sdv.ee.ieo"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://hal.science/hal-05780619/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-24",
  "publisher": "National Academy of Sciences",
  "ris": "https://research.draconitic.com/paper/16wxgtmervqp3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "hal-05780619",
      "source": "hal",
      "url": "https://hal.science/hal-05780619v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ee",
      "subfield": "ecology"
    }
  ],
  "title": "A transcription factor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigation",
  "title_text": "A transcription factor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/16wxgtmervqp3",
  "venue": "Proceedings of the National Academy of Sciences of the United States of America",
  "versions": []
}