{
  "abstract": "Infected wounds require therapeutic materials that can control bacterial infection without aggravating oxidative tissue damage. Here, glutathione-derived carbon dots (GSH-CDs) were introduced during the formation of a cerium metal-organic framework (Ce MOF) through an in situ integration strategy to construct a carbon-dot-integrated Ce MOF nanozyme (Ce MOF-CD). Electronic-structure analyses supported interfacial electron redistribution from GSH-CDs toward Ce MOF, accompanied by changes in the local electronic environment and Ce 3+ /Ce 4+ distribution of the Ce active centers. Ce MOF-CD exhibited a distinct pH-dependent redox catalytic preference, with oxidase-like catalysis favored under acidic conditions and superoxide dismutase-like activity becoming more pronounced near neutrality. Accordingly, Ce MOF-CD markedly reduced the viability of MRSA and E. coli and disrupted established biofilms under acidic conditions. Under near-neutral cellular conditions, it reduced intracellular oxidative stress, attenuated inflammatory activation, and promoted repair-associated macrophage polarization. In an MRSA-infected wound model, Ce MOF-CD reduced bacterial burden and local inflammation, promoted tissue reconstruction, and accelerated wound closure with favorable biosafety. Overall, GSH-CDs-mediated interfacial electronic regulation modulates the pH-dependent redox catalytic behavior of Ce MOF, enabling antibacterial activity to be coordinated with oxidative-stress regulation during infected wound healing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong, China",
    "Department of Prosthodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, 510182, China",
    "Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong, China; Corresponding author. Department of Endodontics, School and Hospital of Stomatology, Medical University, , No. 195 Dongfeng West Road, Yuexiu District, Guangzhou, 020-81299942, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yaping Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Kaichen Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yunxin Ye"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinyi Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Ling Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Ziya Lao"
    },
    {
      "affs": [
        1
      ],
      "name": "Yifan Wu"
    },
    {
      "name": "Tao Luo"
    },
    {
      "affs": [
        2
      ],
      "name": "Li Yang"
    },
    {
      "name": "Lvhua Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/175adew7jx54x.bib",
  "cited_by": 0,
  "doi": "10.1016/j.redox.2026.104398",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2213231726003976",
  "id": "175adew7jx54x",
  "issns": [
    "2213-2317"
  ],
  "landing_url": "https://doi.org/10.1016/j.redox.2026.104398",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2505|Advanced Nanomaterials in Catalysis"
    ]
  ],
  "openalex": "W7212362639",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2213231726003976/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/175adew7jx54x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:17Z",
      "native_id": "fcd253c01779415bb128b4bc4a8fee13",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.redox.2026.104398"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Advanced Nanomaterials in Catalysis",
      "subfield": "materials-polymers"
    }
  ],
  "title": "GSH-derived carbon dot-mediated interfacial electron transfer modulates pH-Dependent redox catalysis of Ce-MOF nanozymes for wound healing",
  "title_text": "GSH-derived carbon dot-mediated interfacial electron transfer modulates pH-Dependent redox catalysis of Ce-MOF nanozymes for wound healing",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:17Z",
  "url": "https://research.draconitic.com/paper/175adew7jx54x",
  "venue": "Redox Biology",
  "versions": []
}