{
  "abstract": "Aims: To compare polymeric micellar paclitaxel (pm-PTX) and albumin-bound paclitaxel (nab-PTX) in first-line immunochemotherapy for advanced esophageal squamous cell carcinoma (ESCC).\n\nPatients and method: We included 109 patients in efficacy and cost-effectiveness analyses (pm-PTX, n = 51; nab-PTX, n = 58) and 112 treatment initiators in safety analyses (pm-PTX, n = 52; nab-PTX, n = 60). Progression-free and overall survival (PFS and OS) were analyzed using Kaplan–Meier and overlap-weighted Cox models.\n\nResults: Median PFS was 10.2 versus 16.7 months (pm-PTX vs nab-PTX, log-rank p = 0.148). After overlap weighting, no significant differences were observed in PFS (hazard ratio [HR], 0.83; 95% confidence interval [CI], 0.43–1.59; p = 0.574) or OS (HR, 1.32; 95% CI, 0.55–3.13; p = 0.536). OS analysis was immature. Response and disease control rates did not differ significantly. Any-grade gastrointestinal reactions, cough, and grade 3–4 anemia and neutropenia were more frequent with pm-PTX (40.4% vs. 10.0%, 11.5% vs. 0.0%, 7.7% vs. 0.0%, and 28.8% vs. 13.3%; p < 0.001, 0.009, 0.044, and 0.060, respectively). Taxane costs were higher with pm-PTX under Chinese pricing.\n\nConclusions: No statistically significant efficacy differences were observed. Both regimens showed manageable but distinct safety profiles; nab-PTX may be economically favorable.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacy, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, China",
    "Department of Critical Care Medicine, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China",
    "Department of Pharmacy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China",
    "Department of Radiation Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China",
    "Office of Ethics Committee, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Weiping He",
      "orcid": "0009-0000-5763-0802"
    },
    {
      "affs": [
        1
      ],
      "name": "Lingli Chen",
      "orcid": "0009-0001-2715-3950"
    },
    {
      "affs": [
        2
      ],
      "name": "Shuangjia Huang",
      "orcid": "0009-0004-8968-7482"
    },
    {
      "affs": [
        3
      ],
      "name": "Pengwei Yan",
      "orcid": "0009-0004-8160-7097"
    },
    {
      "affs": [
        4
      ],
      "name": "Xiaolin Liu",
      "orcid": "0009-0009-5621-6066"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/17fwj1hk9the2.bib",
  "cited_by": 0,
  "doi": "10.1080/17435889.2026.2752930",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733575/",
  "id": "17fwj1hk9the2",
  "issns": [
    "1743-5889",
    "1748-6963"
  ],
  "landing_url": "https://doi.org/10.1080/17435889.2026.2752930",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2746|Esophageal Cancer Research and Treatment"
    ]
  ],
  "openalex": "W7224515136",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/17435889.2026.2752930?needAccess=true",
  "pmcid": "PMC13733575",
  "pmid": "42954041",
  "published": "2026-10-29",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/17fwj1hk9the2.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:19Z",
      "native_id": "PMC13733575",
      "source": "pmc",
      "url": "https://doi.org/10.1080/17435889.2026.2752930"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Esophageal Cancer Research and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Real-world effectiveness of polymeric micellar paclitaxel versus albumin-bound paclitaxel in advanced esophageal squamous cell carcinoma: a retrospective study",
  "title_text": "Real-world effectiveness of polymeric micellar paclitaxel versus albumin-bound paclitaxel in advanced esophageal squamous cell carcinoma: a retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:19Z",
  "url": "https://research.draconitic.com/paper/17fwj1hk9the2",
  "venue": "Nanomedicine",
  "versions": []
}