{
  "abstract": "PURPOSE: O-labeled saline and gadolinium (Gd)-based contrast agents have been applied to investigate CSF dynamics using MRI in preclinical settings, studies in non-human primates remain limited. This study evaluated the feasibility of visualizing CSF kinetics in cynomolgus monkeys using these 2 tracers. METHODS: O-labeled saline protocol, T2-weighted images were acquired every minute for 20 min. For the Gd-DOTA protocol, T1-weighted images were acquired at 10 min, 30 min, 1 hr, 4 hr, and 24 hr after administration. Signal intensities (SIs) within CSF and parenchymal regions were analyzed. RESULTS: O-labeled saline injection, the % change in SI in the cisterna magna peaked rapidly at 2-3 min and subsequently propagated caudally along the cervical spinal canal without detectable parenchymal uptake. In contrast, after Gd-DOTA administration, the % change in SI in the cisterna magna reached its maximum at 1-4 hr, with widespread distribution into ventricles, cisterns, and spinal canal. Gd-DOTA clearance via the cribriform plate was evident. Parenchymal enhancement was observed in the cerebellum, pons, and cingulate gyrus with greater signal change in superficial compared to sub-superficial layers. Marked enhancement was also observed in gray matter surrounding the spinal central canal at 4 hr. CONCLUSION: O-labeled saline enabled rapid visualization of bulk CSF flow, Gd-DOTA provided insights into slower CSF distribution and parenchymal transport. These findings provide a translational platform for future investigations into age- and disease-related alterations in CSF dynamics.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Shohei Chatani"
    },
    {
      "name": "Tatsuya Oki"
    },
    {
      "name": "Sayaka Misaki"
    },
    {
      "name": "Neil Roberts"
    },
    {
      "name": "Yoshiyuki Watanabe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/17he5yfmrcn3p.bib",
  "cited_by": 0,
  "doi": "10.2463/mrms.mp.2026-0048",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/mrms/25/4/25_mp.2026-0048/_article",
  "id": "17he5yfmrcn3p",
  "issns": [
    "1880-2206",
    "1347-3182"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/mrms/25/4/25_mp.2026-0048/_article",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/imaging"
    ],
    [
      "openalex",
      "2741|Advanced MRI Techniques and Applications"
    ]
  ],
  "openalex": "W7223198392",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/17he5yfmrcn3p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "10.2463/mrms.mp.2026-0048",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/mrms/25/4/25_mp.2026-0048/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Advanced MRI Techniques and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "MR Imaging-based Evaluation of Cerebrospinal Fluid Dynamics in Cynomolgus Monkeys Using ¹⁷O-labeled Saline and Gd-DOTA",
  "title_text": "MR Imaging-based Evaluation of Cerebrospinal Fluid Dynamics in Cynomolgus Monkeys Using ¹⁷O-labeled Saline and Gd-DOTA",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/17he5yfmrcn3p",
  "venue": "Magnetic Resonance in Medical Sciences",
  "versions": []
}