{
  "abstract": "Skull base osteomyelitis (SBO) is a rare and potentially life-threatening infection often complicated by multiple cranial nerve palsies. A case of SBO, complicated by multiple cranial nerve palsies, in which antimicrobial therapy was guided by gallium scintigraphy uptake, resulting in a favorable clinical course without recurrence, is reported. A 79-year-old man presented with right otalgia, otorrhea, hearing loss, and facial nerve paralysis. He was initially diagnosed with otitis media-related labyrinthitis and treated with antibiotics and corticosteroids. Two months later, the patient developed recurrent otorrhea and multiple cranial neuropathies. Contrast-enhanced computed tomography/magnetic resonance imaging revealed bone destruction and strong enhancement from the petrous apex to the clivus and nasopharynx. The patient was diagnosed with SBO and was administered intravenous antibiotics for 2 months. Oral antibiotics were continued for approximately 3 months post-discharge. Gallium-67 scintigraphy revealed near-complete resolution 5 months after discharge; accordingly, oral antibiotics were discontinued at that time. No recurrences were observed during 18 months of follow-up. This case highlights the importance of considering SBO in patients with cranial neuropathies, even when initial middle ear findings improve. Long-term culture-directed antibiotics guided by functional imaging, such as gallium scintigraphy, can optimize treatment, prevent recurrence, and improve outcomes in severe cases.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology Head and Neck surgery, Kumamoto University , Kumamoto, Kumamoto Prefecture 860-8555, Japan."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hiroki Takeda"
    },
    {
      "affs": [
        0
      ],
      "name": "Momoko Ise"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryota Kiwaki"
    },
    {
      "affs": [
        0
      ],
      "name": "Takemasa Terao"
    },
    {
      "affs": [
        0
      ],
      "name": "Minori Natsumeda"
    },
    {
      "affs": [
        0
      ],
      "name": "Yorihisa Orita"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/17ma20xaf57vw.bib",
  "cited_by": 0,
  "doi": "10.26599/joto.2026.9540074",
  "fulltext_url": "https://europepmc.org/articles/PMC13740633",
  "id": "17ma20xaf57vw",
  "issns": [
    "1672-2930",
    "2524-1753"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996651",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Otolaryngology and Infectious Diseases"
    ]
  ],
  "openalex": "W7225190297",
  "pdf_url": "https://europepmc.org/articles/PMC13740633?pdf=render",
  "pmcid": "PMC13740633",
  "pmid": "42996651",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/17ma20xaf57vw.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42996651",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996651"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Otolaryngology and Infectious Diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Gallium Scintigraphy-Guided Discontinuation of Antibiotics in Skull Base Osteomyelitis: A Case Report.",
  "title_text": "Gallium Scintigraphy-Guided Discontinuation of Antibiotics in Skull Base Osteomyelitis: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/17ma20xaf57vw",
  "venue": "Journal of otology",
  "versions": []
}