{
  "abstract": "Plasmacytoid dendritic cells (pDCs) detect microbial DNA via endosomal Toll-like receptor 9 (TLR9), yet the mechanisms by which they selectively internalize specific bacteria remain unclear. We demonstrate that type I interferon (IFN-I) responses to lactic acid bacteria (LAB) are entirely dependent on phagocytosis and exhibit pronounced strain specificity. Among tested strains, Lactococcus lactis strain Plasma (LC-Plasma) was efficiently phagocytosed and potently induced IFN-α in both primary human pDCs and CAL-1 cells, whereas closely related strains showed minimal uptake and cytokine production. Phagocytosis was essential for TLR9-dependent IFN-α secretion. Transcriptomic and functional analyses identified BDCA2, a galactose-binding C-type lectin receptor, as a key mediator of LAB uptake. Blocking BDCA2 significantly impaired both phagocytosis and cytokine responses. BDCA2-Fc fusion proteins bound strongly to LAB. Glycan profiling identified glycan signatures associated with highly phagocytosed Lactococcus strains. These findings define BDCA2-dependent phagocytosis as a critical determinant of strain-specific LAB recognition by human pDCs.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Shota Hori",
      "orcid": "0000-0001-8991-3014"
    },
    {
      "name": "Yu Hirose"
    },
    {
      "name": "Julia Matsuo-Dapaah",
      "orcid": "0000-0002-7007-6620"
    },
    {
      "name": "Jiawen Zheng"
    },
    {
      "name": "Toshikazu Tsuji"
    },
    {
      "name": "Hirotaka Fujita"
    },
    {
      "name": "Muneaki Nanao"
    },
    {
      "name": "Ryohei Tsuji"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/17s2gwc90t0q1.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.118033",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720685/?tool=EBI",
  "id": "17s2gwc90t0q1",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03416-4",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Biological sciences"
    ],
    [
      "heading",
      "Integrative aspects of cell biology"
    ],
    [
      "heading",
      "Microbial interactions"
    ],
    [
      "heading",
      "Microbiology"
    ],
    [
      "heading",
      "Molecular microbiology"
    ],
    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
    ]
  ],
  "openalex": "W7223319978",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720685/pdf/?tool=EBI",
  "pmcid": "PMC13720685",
  "pmid": "42964843",
  "published": "2026-10-23",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/17s2gwc90t0q1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.118033",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03416-4"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.118033",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226034164"
    },
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13720685",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720685"
    },
    {
      "first_seen": "2026-11-03T12:21:31Z",
      "native_id": "PMC13720685",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.118033"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "BDCA2-dependent phagocytosis enables strain-specific activation of plasmacytoid dendritic cells by lactic acid bacteria",
  "title_text": "BDCA2-dependent phagocytosis enables strain-specific activation of plasmacytoid dendritic cells by lactic acid bacteria",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:31Z",
  "url": "https://research.draconitic.com/paper/17s2gwc90t0q1",
  "venue": "iScience",
  "versions": []
}