{
  "abstract": "Recent innovations have broadened the potential of electrochemical nucleic acid biosensors for advanced healthcare diagnostics, including point-of-care use in resource-limited and remote environments. Traditional diagnostic platforms are often complex and expensive, making them inaccessible in remote areas. Electrochemical nucleic acid biosensors are simple, fast, affordable, portable, require minimal samples, and are highly specific, addressing these challenges. This review systematically evaluates recent developments in the design and implementation of nucleic acid biosensors, emphasizing strategies for nucleic acid immobilization, innovative dimensional probe architectures, and advanced signal amplification techniques (target-based and signal-based). Furthermore, it critically examines their real-world applications in detecting critical blood-based disease markers associated with infectious diseases, cancers, and genetic disorders. This review also outlines future perspectives and key challenges in the clinical translation of these advanced biosensors, proposing strategic pathways toward intelligent and accessible healthcare solutions for remote communities and extreme environments.",
  "abstract_shown": true,
  "affiliations": [
    "Artificial Intelligence and Cyber Security (AICF), Charles Sturt University, Orange 2800, Australia",
    "Rural Health Research Institute (RHRI), Charles Sturt University, Orange 2800, Australia",
    "ARC Centre of Excellence Plants for Space, Adelaide University, Australia",
    "School of Chemical Engineering, Adelaide University, Adelaide 5005, Australia",
    "Department of Mathematical and Physical Sciences, School of Computing, Engineering and Mathematical Science, La Trobe University, Bundoora, VIC 3086, Australia",
    "The Biomedical and Environmental Sensor Technology (BEST) Research Centre, Biosensors Program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria 3086, Australia",
    "School of Computing, Mathematics and Engineering, Charles Sturt University, Bathurst, NSW 2795, Australia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Abdullah Al Mahmud",
      "orcid": "0009-0002-2733-0475"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Mohammad Boshir Ahmed",
      "orcid": "0000-0003-4756-595X"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Brian Abbey",
      "orcid": "0000-0001-6504-0503"
    },
    {
      "affs": [
        6
      ],
      "name": "Ashad Kabir"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Volker Hessel",
      "orcid": "0000-0002-9494-1519"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mohammad Ali Moni",
      "orcid": "0000-0003-0756-1006"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/17wb9gs9b2hn2.bib",
  "cited_by": 11,
  "doi": "10.1016/j.trac.2026.118959",
  "fulltext_url": null,
  "id": "17wb9gs9b2hn2",
  "issns": [
    "0165-9936",
    "0167-2940",
    "1879-3142"
  ],
  "landing_url": "https://doi.org/10.1016/j.trac.2026.118959",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Advanced biosensing and bioanalysis techniques"
    ]
  ],
  "openalex": "W7163772310",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-06",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/17wb9gs9b2hn2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:46Z",
      "native_id": "W7163772310",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.trac.2026.118959"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Advanced biosensing and bioanalysis techniques",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Electrochemical nucleic acid biosensors: Advancing blood-based diagnostics toward intelligent healthcare in resource-limited settings",
  "title_text": "Electrochemical nucleic acid biosensors: Advancing blood-based diagnostics toward intelligent healthcare in resource-limited settings",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:07Z",
  "url": "https://research.draconitic.com/paper/17wb9gs9b2hn2",
  "venue": "TrAC Trends in Analytical Chemistry",
  "versions": []
}