{
  "abstract": "Late-stage molecular editing is vital for drug diversification and SAR studies. However, programmable peroxide-based editing handles for amides, α-amino acids, peptide- and drug-relevant scaffolds remain largely unexplored, particularly N-acyl hemiperaminals. Inspired by the molecular editing conception for the bioactive skeleton of artemisinin, we report herein efficient syntheses of structurally diverse N-acyl hemiperaminals via aerobic photocatalytic α-amido C–H oxidative functionalization and oxidative decarboxylative coupling of α-amino acids. Notably, the oxidative decarboxylative of dipeptides and tripeptides facilitates the late-stage modification of peptidomimetic drugs and drug-derived scaffolds. Investigations into the chemical properties of N-acyl hemiperaminals suggest their potential as programmable molecular editing handles for the facile construction of α-amido C–C bonds via Lewis acid-catalyzed nucleophilic substitution and titanocene-catalyzed radical cross-coupling. Importantly, as the derivatives, O-alkylated peroxides exhibit potent antimalarial activity, and 6-amido-1,2,4-trioxanes demonstrate powerful and broad-spectrum anticancer activities. This work will enhance the investigation and application of organic peroxides, advancing novel pharmaceuticals by establishing these peroxides as versatile editing linchpins.",
  "abstract_shown": true,
  "affiliations": [
    "Xiamen University , , , ,",
    "Chinese Academy of Sciences , , 300 Feng Lin Road , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuda Li",
      "orcid": "0009-0000-8114-8872"
    },
    {
      "affs": [
        1
      ],
      "name": "Han Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianliang Ye",
      "orcid": "0000-0003-1488-7311"
    },
    {
      "affs": [
        0
      ],
      "name": "Hangtao Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Qian Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Dunpu Rao"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Lihua Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Duanqiu Zuo"
    },
    {
      "affs": [
        0
      ],
      "name": "Ting Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Sibao Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xianming Deng",
      "orcid": "0000-0002-9354-5864"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Zheng",
      "orcid": "0000-0001-7634-0042"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/17xrh5yh8fe1b.bib",
  "cited_by": 0,
  "doi": "10.1021/jacsau.6c00996",
  "fulltext_url": "https://europepmc.org/articles/PMC13714836",
  "id": "17xrh5yh8fe1b",
  "issns": [
    "2691-3704"
  ],
  "landing_url": "https://pubs.acs.org/jaaucr/article/6/10/5577/5444890/N-Acyl-Hemiperaminals-From-Bioactive-Skeleton",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Letter"
    ],
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7220455620",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/jacsau.6c00996",
  "pmcid": "PMC13714836",
  "pmid": "42953175",
  "published": "2026-10-05",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/17xrh5yh8fe1b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:36Z",
      "native_id": "10.1021/jacsau.6c00996",
      "source": "crossref",
      "url": "https://pubs.acs.org/jaaucr/article/6/10/5577/5444890/N-Acyl-Hemiperaminals-From-Bioactive-Skeleton"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953175",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953175"
    },
    {
      "first_seen": "2026-11-01T12:22:15Z",
      "native_id": "PMC13714836",
      "source": "pmc",
      "url": "https://doi.org/10.1021/jacsau.6c00996"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "N -Acyl Hemiperaminals: From Bioactive Skeleton Editing of Artemisinin to Programmable Handles for α-Amido Functionalization and Bioactive Peroxides",
  "title_text": "N -Acyl Hemiperaminals: From Bioactive Skeleton Editing of Artemisinin to Programmable Handles for α-Amido Functionalization and Bioactive Peroxides",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:15Z",
  "url": "https://research.draconitic.com/paper/17xrh5yh8fe1b",
  "venue": "JACS Au",
  "versions": []
}