{ "abstract": "Aims: Inaugural presentation at type 1 diabetes onset, as ketoacidosis, has been associated with poorer glycaemic control, but its relationship to diabetes‐related complications remains unclear. We assessed the association between inaugural intensive care unit (ICU) admission and long‐term diabetes‐related outcomes in adults.\n\nMaterials and Methods: This cross‐sectional analysis used data from the Société Francophone du Diabète—Cohorte Diabète de Type 1 (SFDT1) cohort. We compared participants with and without an inaugural ICU admission regarding chronic complications, recent acute events, and cardiometabolic risk factors. Models were adjusted for age, sex, diabetes duration, smoking status, socioeconomic vulnerability, education, insulin therapy, HbA1c, and centre; interaction terms were tested.\n\nResults: Among 3548 adults with type 1 diabetes (median duration 20 years [IQR 10–30]), 377 (10.6%) reported inaugural ICU admission. Retinopathy was more prevalent in the ICU group (36.6 vs. 31.4%; p < 0.05), including proliferative forms (11.1 vs. 7.7%; p < 0.05). These differences remained significant after adjustment (p < 0.05). An association with retinopathy was observed among individuals diagnosed before the age of 17 (OR = 1.5; 95% CI, 1.1–2.1; p = 0.015). Severe hypoglycaemia in the previous year was more frequent in the ICU group (15.4% vs. 10.5%; p < 0.01) and remained significant after adjustment (p < 0.05). No significant differences were observed for the other variables.\n\nConclusions: In this multicentre cohort of adults with long‐standing type 1 diabetes, inaugural ICU was associated with at least a 50% higher odds of severe hypoglycaemia and retinopathy, including proliferative forms. The association with retinopathy was mainly observed among individuals diagnosed at a young age.\n\nTrial Registration: ClinicalTrials.gov (NCT04657783)", "abstract_shown": true, "affiliations": [ "Department of Endocrinology, Diabetology and Nutrition, Avicenne Hospital Assistance Publique–Hôpitaux de Paris (AP‐HP) Bobigny France", "Clinical Research Center in Human Nutrition (CRNH‐IdF), Île‐de‐France Nord Specialized Center for Obesity (CSO) University Sorbonne Paris Nord Bobigny France", "Nutritional Epidemiology Research Team (EREN), Center for Research in Epidemiology and Statistics (CRESS) University Sorbonne Paris Nord and Paris Cité University, INSERM, INRAE, CNAM Bobigny France", "Department of Precision Health, Deep Digital Phenotyping Unit Luxembourg Institute of Health Strassen Luxembourg", "Sanofi Gentilly France", "Department of Endocrinology and Diabetology Montpellier University Hospital, University of Montpellier, INSERM, CNRS Montpellier France", "Department of Diabetology and Endocrinology, Bichat Hospital Assistance Publique – Hôpitaux de Paris (AP‐HP) Paris France", "INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, Université Paris Cité Paris France", "Department of Endocrinology and Diabetology European Hospital Marseille France", "Department of Diabetology, Cochin Hospital Assistance Publique – Hôpitaux de Paris (AP‐HP) Paris France", "Department of Pediatric Endocrinology and Diabetology, Ambulatory Care Platform Grenoble Alpes University Hospital Grenoble France", "Service de Diabètes et Endocrinologie, Hôpital Lariboisière AP‐HP Paris France", "Équipe Immunité et Métabolisme du Diabète Université Paris Cité, INSERM UMR‐S1151, CNRS UMR‐S8253, Institut Necker Enfants Malades Paris France" ], "article_type": "research article", "arxiv": null, "author_total": 11, "authors": [ { "affs": [ 0, 1, 2 ], "name": "Emmanuel Cosson", "orcid": "0000-0002-8785-3385" }, { "affs": [ 3 ], "name": "Gloria Aguayo", "orcid": "0000-0002-5625-1664" }, { "affs": [ 4 ], "name": "Amandine Créquer‐Grandhomme", "orcid": "0000-0003-4866-7085" }, { "affs": [ 4 ], "name": "Amar Bahloul", "orcid": "0000-0003-4548-5059" }, { "affs": [ 5 ], "name": "Eric Renard", "orcid": "0000-0002-3407-7263" }, { "affs": [ 6, 7 ], "name": "Louis Potier", "orcid": "0000-0001-6268-7360" }, { "affs": [ 8 ], "name": "Pauline Schaepelynck", "orcid": "0000-0002-4301-5531" }, { "affs": [ 9 ], "name": "Agnès Sola‐Gazagnes", "orcid": "0000-0002-1091-897X" }, { "affs": [ 10 ], "name": "Anne Spiteri", "orcid": "0009-0008-8198-7674" }, { "affs": [ 11, 12 ], "name": "Jean‐Pierre Riveline", "orcid": "0000-0001-7991-0741" }, { "affs": [ 3 ], "name": "Guy Fagherazzi", "orcid": "0000-0001-5033-5966" } ], "bibtex": "https://research.draconitic.com/paper/18cb38jz084x2.bib", "cited_by": 0, "doi": "10.1111/dom.71393", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730991/", "id": "18cb38jz084x2", "issns": [ "1462-8902", "1463-1326" ], "landing_url": "https://doi.org/10.1111/dom.71393", "language": "en", "licence": "CC-BY-NC-ND-4.0", "licence_label": "CC BY-NC-ND 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Original Article" ], [ "openalex", "2712|Diabetes Management and Research" ] ], "openalex": "W7216231720", "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.71393", "pmcid": "PMC13730991", "pmid": "42823888", "published": "2026-10-02", "publisher": null, "ris": "https://research.draconitic.com/paper/18cb38jz084x2.ris", "sources": [ { "first_seen": "2026-11-08T12:21:17Z", "native_id": "PMC13730991", "source": "pmc", "url": "https://doi.org/10.1111/dom.71393" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2712|Diabetes Management and Research", "subfield": "endocrinology-metabolism" } ], "title": "Prevalence of Chronic Complications After Inaugural Admission in Intensive Care Unit for Type 1 Diabetes in the SFDT1 Cohort: The INAUGURAL Study", "title_text": "Prevalence of Chronic Complications After Inaugural Admission in Intensive Care Unit for Type 1 Diabetes in the SFDT1 Cohort: The INAUGURAL Study", "type": "peer-reviewed", "updated_at": "2026-11-08T12:21:17Z", "url": "https://research.draconitic.com/paper/18cb38jz084x2", "venue": "Diabetes, Obesity & Metabolism", "versions": [] }