{
  "abstract": "Co-assembly and self-sorting in multicomponent systems are typically treated as mutually exclusive outcomes. Here, we show that this distinction is incomplete. Using enantiomeric peptide nanotubes, we demonstrate that a single co-assembled structure forms only at an equimolar composition, yet remains internally self-sorted into compositionally distinct domains. Contrast-matched neutron scattering directly reveals this segregation and shows that the co-assembled structures adopt layered architectures rather than simple molecular-level mixing. These results establish that co-assembly and self-sorting can coexist within a single supramolecular object across length scales, providing a general framework for understanding and controlling multicomponent self-assembly.",
  "abstract_shown": true,
  "affiliations": [
    "MAX IV Laboratory, Lund University Lund 224 84 Sweden",
    "School of Chemistry, University of Glasgow Glasgow G12 8QQ UK",
    "Department of Biochemistry and Molecular Genetics, University of Virginia Charlottesville VA 22903 USA",
    "ISIS Pulsed Neutron and Muon Source Harwell Science and Innovation Campus Didcot OX11 0QX UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Simona Bianco",
      "orcid": "0000-0001-5305-8546"
    },
    {
      "affs": [
        2
      ],
      "name": "Ravi R. Sonani",
      "orcid": "0000-0002-6212-2869"
    },
    {
      "affs": [
        1
      ],
      "name": "Libby J. Marshall",
      "orcid": "0000-0001-7276-8754"
    },
    {
      "affs": [
        1
      ],
      "name": "Alex S. Loch",
      "orcid": "0000-0001-7475-2529"
    },
    {
      "affs": [
        3
      ],
      "name": "James Doutch"
    },
    {
      "affs": [
        2
      ],
      "name": "Edward H. Egelman",
      "orcid": "0000-0003-4844-5212"
    },
    {
      "affs": [
        1
      ],
      "name": "Dave J. Adams",
      "orcid": "0000-0002-3176-1350"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/18mj2h6x9a6ck.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc04454a",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13541071/",
  "id": "18mj2h6x9a6ck",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc04454a",
  "language": "en",
  "licence": "CC-BY-3.0",
  "licence_label": "CC BY 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2502|Supramolecular Self-Assembly in Materials"
    ]
  ],
  "openalex": "W7204494351",
  "pdf_url": null,
  "pmcid": "PMC13541071",
  "pmid": "42695060",
  "published": "2026-08-27",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/18mj2h6x9a6ck.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:44Z",
      "native_id": "PMC13541071",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc04454a"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Supramolecular Self-Assembly in Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Co-assembly and self-sorting are not mutually exclusive in enantiomeric peptide systems",
  "title_text": "Co-assembly and self-sorting are not mutually exclusive in enantiomeric peptide systems",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:52Z",
  "url": "https://research.draconitic.com/paper/18mj2h6x9a6ck",
  "venue": "Chemical Science",
  "versions": []
}