{
  "abstract": "Plants are important sources for obtaining diverse secondary metabolites which have pharmaceutical importance. Out of multiple factors that modulate their accumulation in vitro and in vivo, epigenetic factors play critical roles, adding an extra layer of regulation. This review focuses on (a) dynamic changes that occur in DNA methylation, histone acetylation, and the role of small RNAs in transcriptional and post-transcriptional modulation that alter secondary metabolism in plants under abiotic stress and (b) the role of epigenetics in secondary metabolite accumulation in the plant cell cultures. Such epigenetic factors are manipulated by applying inhibitors of DNA methylation like 5-azacytidine or histone deacetylation such as trichostatin A in intact plants as well as in cultured plant cells and hairy roots for enhanced production. This article synthesizes current findings on epigenetic engineering for improved synthesis of anticancer compounds and nutraceuticals and lists out limitations and challenges that the pharmaceutical industry is facing for their large scale production and commercialization. Main conclusion: Through epigenetic changes such as DNA methylation, histone acetylation, and non-coding RNAs, plants dynamically fine-tune specific gene expressions to adjust to environmental stresses and mediate secondary metabolite accumulation as a chemical combat mechanism.",
  "abstract_shown": true,
  "affiliations": [
    "Independent Researcher, Dallas, TX 75201, USA.",
    "Center for Plant Molecular Biology, Department of Genetics, Osmania University, Hyderabad 500007, India.",
    "MVSR Engineering College, Nadergul, Hyderabad 501510, India.",
    "Acute Care Physical Therapist, St. Luke's Health, 1717 US-59 Loop North, Livingston, TX 77351, USA.",
    "International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Hyderabad 502324, India.",
    "International Rice Research Institute, DAPO Box 7777, Metro Manila 1301, Philippines.",
    "Department of Agriculture, Dr. RVR NRI Institute of Technology (Deemed to be University), Pothavarappadu, Vijayawada Rural 521212, India."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Deekshitha Kosaraju",
      "orcid": "0009-0000-3111-3241"
    },
    {
      "affs": [
        1
      ],
      "name": "Viswanadha Naik Jarapala",
      "orcid": "0009-0002-2812-3099"
    },
    {
      "affs": [
        2
      ],
      "name": "Aparna Yeddala",
      "orcid": "0000-0001-7027-315X"
    },
    {
      "affs": [
        3
      ],
      "name": "Charumathi Polavarapu"
    },
    {
      "affs": [
        4
      ],
      "name": "Vasavi Singareddy",
      "orcid": "0000-0001-6324-8845"
    },
    {
      "affs": [
        4
      ],
      "name": "Sudhakar Reddy Palakolanu"
    },
    {
      "affs": [
        5
      ],
      "name": "Nese Sreenivasulu"
    },
    {
      "affs": [
        6
      ],
      "name": "Polavarapu Bilhan Kavi Kishor",
      "orcid": "0000-0002-9587-7547"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/18tmt5ejhgssj.bib",
  "cited_by": 0,
  "doi": "10.3390/epigenomes10040066",
  "fulltext_url": "https://europepmc.org/articles/PMC13692425",
  "id": "18tmt5ejhgssj",
  "issns": [
    "2075-4655"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924725",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Plant tissue culture and regeneration"
    ]
  ],
  "openalex": "W7221527683",
  "pdf_url": "https://europepmc.org/articles/PMC13692425?pdf=render",
  "pmcid": "PMC13692425",
  "pmid": "42924725",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/18tmt5ejhgssj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42924725",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924725"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Plant tissue culture and regeneration",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Epigenetic Landscape and Regulation of Secondary Metabolite Accumulation Implicated in Anticancer and Nutraceuticals.",
  "title_text": "Epigenetic Landscape and Regulation of Secondary Metabolite Accumulation Implicated in Anticancer and Nutraceuticals.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/18tmt5ejhgssj",
  "venue": "Epigenomes",
  "versions": []
}