{
  "abstract": "Immune cells elicit a continuum of transcriptional states after spinal cord injury (SCI). In mammals, inefficient debris clearance and chronic inflammation impede recovery and overshadow pro-regenerative immune functions. We found that zebrafish SCI elicits transient immune activation and efficient debris clearance. Transcriptomics and genetic ablation showed zebrafish macrophages are highly phagocytic and required for regeneration. Comparisons between zebrafish and mammalian macrophages identified transcription and immune response regulator (tcim) as an immune-enriched regenerative gene. Deletion of zebrafish tcim impairs phagocytosis and regeneration and activates a pro-inflammatory signature in leukocytes. Tcim expression in zebrafish and mouse macrophages establishes its conserved roles by promoting lipid metabolism and the reprogramming of myeloid precursors into activated phagocytes. This study underscores a requirement for elevated phagocytic capacity to achieve innate spinal cord repair and identifies a gene with conserved function in mammalian cells.",
  "abstract_shown": true,
  "affiliations": [
    "Center of Regenerative Medicine Washington University School of Medicine, St. Louis, MO, USA 6110",
    "Department of Developmental Biology Washington University School of Medicine, St. Louis, MO, USA 630",
    "Hope Center for Neurological Disorders Washington University School of Medicine, St. Louis, MO, USA 63110",
    "Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA",
    "Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA",
    "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M Health Science Center, Houston, TX 77030, USA",
    "Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA",
    "Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: mmokalled@wustl.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Dana Klatt Shaw",
      "orcid": "0000-0003-3299-3070"
    },
    {
      "affs": [
        3,
        0,
        1,
        2
      ],
      "name": "Vishnu Muraleedharan Saraswathy",
      "orcid": "0000-0003-4235-7051"
    },
    {
      "affs": [
        3,
        0,
        1,
        2
      ],
      "name": "Anthony R. McAdow",
      "orcid": "0000-0003-3440-935X"
    },
    {
      "affs": [
        3,
        0,
        1,
        2
      ],
      "name": "Lili Zhou",
      "orcid": "0000-0001-5044-6965"
    },
    {
      "affs": [
        4,
        0,
        1
      ],
      "name": "Dongkook Park"
    },
    {
      "affs": [
        3,
        0,
        1,
        2
      ],
      "name": "Ridim Dadasaheb Mote"
    },
    {
      "affs": [
        3,
        0,
        1
      ],
      "name": "Amulya Saini"
    },
    {
      "affs": [
        5,
        0,
        1,
        2
      ],
      "name": "Ashley J. Douthitt"
    },
    {
      "affs": [
        5
      ],
      "name": "Katerina Stepankova"
    },
    {
      "affs": [
        6
      ],
      "name": "Brittney Unverzagt"
    },
    {
      "affs": [
        5
      ],
      "name": "Cédric G. Geoffroy"
    },
    {
      "affs": [
        4
      ],
      "name": "Aaron N. Johnson",
      "orcid": "0000-0002-2783-5636"
    },
    {
      "affs": [
        7
      ],
      "name": "Mayssa H. Mokalled",
      "orcid": "0000-0002-3712-351X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/198dftcydew7t.bib",
  "cited_by": 12,
  "doi": "10.1016/j.celrep.2026.117482",
  "fulltext_url": null,
  "id": "198dftcydew7t",
  "issns": [
    "2211-1247",
    "2639-1856"
  ],
  "landing_url": "https://doi.org/10.1016/j.celrep.2026.117482",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Spinal Cord Injury Research"
    ]
  ],
  "openalex": "W4399693644",
  "pdf_url": null,
  "pmcid": "PMC11195157",
  "pmid": "38915507",
  "published": "2026-06-01",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/198dftcydew7t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:56Z",
      "native_id": "W4399693644",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.celrep.2026.117482"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Spinal Cord Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Elevated phagocytic capacity directs innate spinal cord repair",
  "title_text": "Elevated phagocytic capacity directs innate spinal cord repair",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T13:21:15Z",
  "url": "https://research.draconitic.com/paper/198dftcydew7t",
  "venue": "Cell Reports",
  "versions": []
}