{
  "abstract": "Objectives: This study sought to determine the prevalence of hepatitis B virus (HBV)-hepatitis D virus (HDV) co-infection and to characterize isolates of both viruses in a Chadian population of HBV surface antigen (HBsAg)-positive pregnant women and students. Methods: This was a cross-sectional retrospective study using archived samples from pregnant women and students in N'djamena who had been systematically screened for HBsAg between April and August 2021. HBsAg-positive samples were tested for the presence of HDV antibodies (Ab) and were screened for the presence of both HBV and HDV (in anti-HDV Ab-positive samples) viral load estimations. Genome sequencing of the viruses was used for both genotyping and phylogenetic analysis. Results: A total of 94 participants were included in this study. The mean age was 24 ± 4.89 years (range: 18-42 years). Anti-HDV Ab were found in 9.57% (9/94) of the participants. The prevalence of anti-HDV Ab positivity among students (6.45% [4/62]) was lower than the 15.63% (5/32) observed among pregnant women. HDV-RNA was detected in 7/9 (77.77%) confirmed anti-HDV-positive participants. Most HDV-RN-positive participants had very low HBV DNA viral loads. All HBV sequences belonged to genotype E and all HDV sequences to genotype 1. Conclusions: Hepatitis D is a potential public health challenge in Chad, which requires active surveillance and public education in the country for proper control. This surveillance should be supported with mass immunization against HBV.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Nalda Debsikréo"
    },
    {
      "name": "Maire Dehainsala"
    },
    {
      "name": "Odan Debsikréo"
    },
    {
      "name": "Nafissatou Leye"
    },
    {
      "name": "Gora Lo"
    },
    {
      "name": "Aminata Dia"
    },
    {
      "name": "Makoutchouang Nzonde Biscotine Flore"
    },
    {
      "name": "Ndeye Aminata Diaw"
    },
    {
      "name": "Ndeye Dieynaba Diouf"
    },
    {
      "name": "Isaac Darko Otchere"
    },
    {
      "name": "Rayana Maryse Toyé"
    },
    {
      "name": "Isabelle Chemin"
    },
    {
      "name": "Ali Mahamat Moussa"
    },
    {
      "name": "Ndèye Coumba Toure-Kane"
    },
    {
      "name": "Françoise Lunel-Fabiani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/19my9wc4jevz6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijregi.2024.100560",
  "fulltext_url": null,
  "id": "19my9wc4jevz6",
  "issns": [
    "2772-7076",
    "2772-7076"
  ],
  "landing_url": "https://hal.science/hal-05840913v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2713|Hepatitis B Virus Studies"
    ]
  ],
  "openalex": "W4405861840",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/19my9wc4jevz6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "hal-05840913",
      "source": "hal",
      "url": "https://hal.science/hal-05840913v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Hepatitis B Virus Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Prevalence and molecular characterization of hepatitis delta virus infection among hepatitis B virus surface antigen positive students and pregnant women in N'djamena, Chad",
  "title_text": "Prevalence and molecular characterization of hepatitis delta virus infection among hepatitis B virus surface antigen positive students and pregnant women in N'djamena, Chad",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/19my9wc4jevz6",
  "venue": "IJID Regions",
  "versions": []
}