{
  "abstract": "Objective\n\nTo identify space-time risk clusters for cases and deaths from severe acute respiratory syndrome (SARS) caused by COVID-19 and to characterize the spatial distribution of vaccination coverage among children and adolescents aged 0-19 years in Brazil.Methods\n\nSpatial analysis study using secondary data from the 5,570 municipalities in Brazil. Cases and deaths from SARS caused by COVID-19 among children and adolescents aged 0-19 years reported between March 2020 and December 2024 in the Influenza Epidemiological Surveillance Information System (Sistema de Informação da Vigilância Epidemiológica da Gripe, SIVEP-Gripe) were included. Vaccination records from January 2021 to December 2024 were analyzed. Vaccination coverage rates were calculated by age group and vaccination schedule. Space-time clusters were identified using the spatial scan technique.Results\n\nA total of 74,470 cases and 3,749 deaths were recorded in the population aged 0-19 years. Significant clusters of high and low risk were identified, including one protective cluster for cases among individuals aged 0-19 years (relative risk [RR] 0.28; 95% confidence interval [95%CI] 0.27; 0.29) and another high-risk cluster for deaths in the North, Northeast, and Central-West regions (RR 3.28; 95%CI 3.00; 3.59). Primary vaccination reached high coverage (85.2%), especially among adolescents aged 15-19 years (96.8%), whereas booster dose coverage remained insufficient (23.1%). The spatial distribution showed heterogeneity, with lower vaccination coverage in the North and Central-West regions.Conclusion\n\nSpace-time inequalities were observed in cases and deaths from severe acute respiratory syndrome (SARS) caused by COVID-19 among children and adolescents, with risk clusters and heterogeneity in vaccination coverage, characterized by high primary coverage and low booster coverage, especially in the North and Central-West regions..",
  "abstract_shown": true,
  "affiliations": [
    "Universidade de São Paulo Escola de Enfermagem de Ribeirão Preto Ribeirão PretoSP Brazil Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Ribeirão Preto, SP, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Reginaldo Bazon Vaz Tavares",
      "orcid": "0000-0002-5378-6962"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan Mathias Alves",
      "orcid": "0000-0002-5596-0047"
    },
    {
      "affs": [
        0
      ],
      "name": "Nathalia Zini",
      "orcid": "0000-0003-1891-1606"
    },
    {
      "affs": [
        0
      ],
      "name": "Ariela Fehr Tártaro",
      "orcid": "0000-0002-2329-6268"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Eduarda Pagano Pelodan",
      "orcid": "0000-0001-7635-9675"
    },
    {
      "affs": [
        0
      ],
      "name": "Luanne Karolyne Leal Dos Santos",
      "orcid": "0009-0001-8263-321X"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniele de Moraes Pinheiro",
      "orcid": "0009-0001-9614-234X"
    },
    {
      "affs": [
        0
      ],
      "name": "Tatiana Ferraz de Araújo Alecrim",
      "orcid": "0000-0002-5991-0135"
    },
    {
      "affs": [
        0
      ],
      "name": "Ricardo Alexandre Arcêncio",
      "orcid": "0000-0003-4792-8714"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/19pztr1pe8my8.bib",
  "cited_by": 0,
  "doi": "10.1590/s2237-962220v35e20251042.en",
  "fulltext_url": "https://europepmc.org/articles/PMC13686397",
  "id": "19pztr1pe8my8",
  "issns": [
    "1679-4974",
    "2237-9622"
  ],
  "landing_url": "https://europepmc.org/article/MED/42922896",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2611|COVID-19 epidemiological studies"
    ]
  ],
  "openalex": "W7170358730",
  "pdf_url": "https://europepmc.org/articles/PMC13686397?pdf=render",
  "pmcid": "PMC13686397",
  "pmid": "42922896",
  "published": "2026-07-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/19pztr1pe8my8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42922896",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42922896"
    }
  ],
  "subjects": [
    {
      "field": "mathematics",
      "origin": "openalex:2611|COVID-19 epidemiological studies",
      "subfield": "general"
    }
  ],
  "title": "Regional inequalities in vaccination coverage and COVID-19 risk among children and adolescents: spatial analysis, Brazil, 2020-2024.",
  "title_text": "Regional inequalities in vaccination coverage and COVID-19 risk among children and adolescents: spatial analysis, Brazil, 2020-2024.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/19pztr1pe8my8",
  "venue": "Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil",
  "versions": []
}