{
  "abstract": "ObjectiveThis study examined the prevalence of psychotic experiences (PE) and how early onset and persistence of PE contribute to risk and severity of mental disorders in adolescents at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and adolescents from a population-based control group (PBC).\n\nMethodsThis is the second follow-up of a nationwide cohort study including 522 children at FHR-SZ (N=202), FHR-BP (N=120), and PBC (N=200). Participants were assessed at ages 7, 11, and 15 using a semi-structured interview to evaluate PE and mental disorders.\n\nResultsAt age 15, adolescents at FHR-SZ reported more PE than PBC over the past six months (current) and the past four years, while adolescents at FHR-BP only reported more current PE. PE reported at two or three timepoints (persistent PE) predicted any Axis I disorder in mid-adolescence, corresponding to three- (OR 2.9, 95% CI [1.5-5.7]) and 21-fold (OR 21.4, 95% CI [2.8-162.3]) increased risks, respectively. Persistent PE also predicted multimorbidity, with three- (OR 2.8, 95% CI [1.0-7.6]) and four-fold (OR 4.1, 95% CI [1.2-14.1]) increased risks, respectively. This was after adjustment for sex, early mental disorders, and familial risk.\n\nConclusionsThis study demonstrates a strong link between persistent PE and mid-adolescence mental disorders. Our findings emphasize PE as important risk markers for mental disorders during mid-adolescence and highlight the importance of monitoring children with PE before age 7 who develop persistent symptoms.",
  "abstract_shown": true,
  "affiliations": [
    "Copenhagen Research Center for Mental Health"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. B. Rohd"
    },
    {
      "name": "A. A. Thorup"
    },
    {
      "name": "M. Wilms"
    },
    {
      "name": "M. Schiavon"
    },
    {
      "name": "D. H. B. Streyma"
    },
    {
      "name": "A. F. Laursen"
    },
    {
      "name": "A. F. Bundgaard"
    },
    {
      "name": "A. Sondergaard"
    },
    {
      "name": "M. F. Krantz"
    },
    {
      "name": "L. Veddum"
    },
    {
      "name": "C. Hjorthoj"
    },
    {
      "name": "A. Greve"
    },
    {
      "name": "O. Mors"
    },
    {
      "name": "M. Nordentoft"
    },
    {
      "name": "N. Hemager"
    },
    {
      "name": "M. Gregersen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/19rrwkpf60aht.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.27.26361507",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.08.27.26361507v1.full",
  "id": "19rrwkpf60aht",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.08.27.26361507v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "psychiatry and clinical psychology"
    ],
    [
      "openalex",
      "2738|Schizophrenia research and treatment"
    ]
  ],
  "openalex": "W7204922878",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.08.27.26361507v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/19rrwkpf60aht.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:28Z",
      "native_id": "10.64898/2026.08.27.26361507",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.08.27.26361507v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:psychiatry and clinical psychology",
      "subfield": "psychiatry"
    }
  ],
  "title": "Persistence of psychotic experiences and clinical outcomes in adolescents at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study",
  "title_text": "Persistence of psychotic experiences and clinical outcomes in adolescents at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:28Z",
  "url": "https://research.draconitic.com/paper/19rrwkpf60aht",
  "venue": "medRxiv",
  "versions": []
}