{
  "abstract": "Introduction: Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation.\n\nMethods: We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion performed in adult patients with haematological diseases between 2013 and 2026 at the Department of Haematology, Skåne University Hospital, Lund, Sweden. In March 2023, the recommended platelet transfusion threshold before CVC insertion was lowered from < 50 × 109/L to < 10 × 109/L. The primary outcome was the proportion of grade 3–4 bleeding events. Secondary outcomes included the proportion of grade 2 bleeding events and transfusion practices.\n\nResults: A total of 992 patients were included (715 before and 277 after implementation). Grade 3–4 bleeding events occurred in 14/715 procedures before implementation and in none of the 277 insertions after implementation (absolute risk difference −2.0%, 95% CI: −3.3 to −0.4; p = 0.014). Grade 2 bleeding events were unchanged (8.5% vs. 6.5%, absolute risk difference −2.0%, 95% CI: −5.2 to 2.0; p = 0.289). Preprocedural platelet transfusions decreased substantially (30% vs. 6.5%; p < 0.001).\n\nConclusions: Lowering the platelet transfusion threshold to < 10 × 109/L was not associated with increased bleeding complications and reduced platelet transfusion use. These findings support a more restrictive preprocedural transfusion strategy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Sciences Lund University Lund Sweden",
    "Department of Intensive and Perioperative Care Skåne University Hospital Lund Sweden",
    "Department of Haematology, Oncology and Radiation Physics Skåne University Hospital Lund Sweden",
    "Department of Cardiothoracic Surgery Anaesthesia and Intensive Care Skåne University Hospital Lund Sweden",
    "Department of Anaesthesia and Perfusion The Prince Charles Hospital Brisbane Queensland Australia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mathias Lazarevic Lindblad",
      "orcid": "0009-0001-2899-2262"
    },
    {
      "affs": [
        0
      ],
      "name": "Elin Pålsson"
    },
    {
      "affs": [
        2
      ],
      "name": "Vladimir Lazarevic",
      "orcid": "0000-0002-1782-4423"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Leila Naddi",
      "orcid": "0000-0002-2711-5866"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Ola Borgquist",
      "orcid": "0000-0002-4921-7310"
    },
    {
      "affs": [
        2
      ],
      "name": "Lars Nilsson"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Maria Adrian",
      "orcid": "0000-0002-9665-3692"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Björn P. Bark",
      "orcid": "0009-0000-9068-6656"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Thomas Kander",
      "orcid": "0000-0002-5404-2981"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1avrfjm13c9hp.bib",
  "cited_by": 0,
  "doi": "10.1111/ejh.70287",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729923/",
  "id": "1avrfjm13c9hp",
  "issns": [
    "0902-4441",
    "1600-0609"
  ],
  "landing_url": "https://doi.org/10.1111/ejh.70287",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2720|Blood transfusion and management"
    ]
  ],
  "openalex": "W7201884059",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.70287",
  "pmcid": "PMC13729923",
  "pmid": "42565516",
  "published": "2026-08-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1avrfjm13c9hp.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:39Z",
      "native_id": "PMC13729923",
      "source": "pmc",
      "url": "https://doi.org/10.1111/ejh.70287"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Blood transfusion and management",
      "subfield": "general"
    }
  ],
  "title": "Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases",
  "title_text": "Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:39Z",
  "url": "https://research.draconitic.com/paper/1avrfjm13c9hp",
  "venue": "European Journal of Haematology",
  "versions": []
}