{
  "abstract": "Equine alphaherpesvirus type 8 (EHV-8) is an economically significant emerging pathogen responsible for severe respiratory disease, reproductive failure, and neurological disorders in equids worldwide. The escalating prevalence of EHV-8 in large-scale donkey farming operations, particularly in China, has resulted in substantial economic losses; however, no licensed antiviral agents or prophylactic vaccines are currently available. In the present study, we evaluated the anti-EHV-8 activity of naringenin in susceptible cells and comprehensively explored the underlying molecular mechanisms. Our results demonstrated that naringenin markedly inhibited EHV-8 infection in RK-13 and NBL-6 cells in a dose-dependent manner. Moreover, naringenin blocked the replication of EHV-8 via HO-1 (heme oxygenase-1)-mediated type I interferon (IFN) response. Collectively, our findings indicate that naringenin may serve as a promising therapeutic drug for the treatment of EHV-8 infection.",
  "abstract_shown": true,
  "affiliations": [
    "College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030600, China.",
    "College of Agriculture and Biology, Liaocheng University, Liaocheng 252000, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Anrong You"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rongze Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Wei Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Enxin Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Muhammad Zahoor Khan",
      "orcid": "0000-0001-5890-2996"
    },
    {
      "affs": [
        1
      ],
      "name": "Liangliang Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Changfa Wang",
      "orcid": "0000-0002-5186-1703"
    },
    {
      "affs": [
        1
      ],
      "name": "Tongtong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Zhao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1b6a3r24ghajd.bib",
  "cited_by": 0,
  "doi": "10.3390/vetsci13101022",
  "fulltext_url": "https://europepmc.org/articles/PMC13709609",
  "id": "1b6a3r24ghajd",
  "issns": [
    "2306-7381"
  ],
  "landing_url": "https://europepmc.org/article/MED/42944118",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Herpesvirus Infections and Treatments"
    ]
  ],
  "openalex": "W7214586053",
  "pdf_url": "https://europepmc.org/articles/PMC13709609?pdf=render",
  "pmcid": "PMC13709609",
  "pmid": "42944118",
  "published": "2026-09-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1b6a3r24ghajd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42944118",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42944118"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Herpesvirus Infections and Treatments",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Antiviral Activity of Naringenin Against Equine Alphaherpesvirus Type 8 In Vitro.",
  "title_text": "Antiviral Activity of Naringenin Against Equine Alphaherpesvirus Type 8 In Vitro.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/1b6a3r24ghajd",
  "venue": "Veterinary sciences",
  "versions": []
}