{
  "abstract": "This case report explored the clinical improvement and short-term tolerability of allogeneic adipose-derived mesenchymal stem cells (AD-MSCs) in the treatment of severe chronic kidney disease (CKD) in dogs. A 9-year-old female Pomeranian was diagnosed with chronic kidney disease (CKD) caused by acute kidney injury and, after conventional treatment failed, received intravenous infusion of AD-MSCs from healthy donor dogs. The AD-MSCs were aseptically collected, isolated, cultured, characterized, and subjected to microbiological safety testing, and were then administered intravenously at a dose of 3 × 10⁶cells/kg every 2 weeks for a total of four infusions, with dexamethasone premedication to reduce the risk of adverse reactions. Following AD-MSC administration and continued conventional care, reductions in serum creatinine and phosphorus and a downward trend in blood urea nitrogen were observed, along with improvements in body weight, body condition score, appetite, and mental status; no adverse events were observed. The results of this case suggest the feasibility and short-term tolerability of allogeneic AD-MSCs for severe CKD in dogs and provide a reference for clinical research on cell-based therapy for canine CKD.",
  "abstract_shown": true,
  "affiliations": [
    "College of Life Sciences, Yantai University, Yantai, Shandong, China.",
    "OUR PET Hospital, Shanghai, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuemin Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyuan Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxin Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiwei Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yizhe Song"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1bbyepn0hf8yg.bib",
  "cited_by": 0,
  "doi": "10.3389/fvets.2026.1977920",
  "fulltext_url": "https://europepmc.org/articles/PMC13683740",
  "id": "1bbyepn0hf8yg",
  "issns": [
    "2297-1769"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909056",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Mesenchymal stem cell research"
    ]
  ],
  "openalex": "W7220832028",
  "pdf_url": "https://europepmc.org/articles/PMC13683740?pdf=render",
  "pmcid": "PMC13683740",
  "pmid": "42909056",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1bbyepn0hf8yg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909056",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909056"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Mesenchymal stem cell research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe chronic kidney disease in a dog.",
  "title_text": "Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe chronic kidney disease in a dog.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/1bbyepn0hf8yg",
  "venue": "Frontiers in veterinary science",
  "versions": []
}