{
  "abstract": "BackgroundEvidence on khat use prevalence is substantial in Ethiopia and elsewhere. However, problematic khat use remains largely unstudied because the concept has not been clearly defined or consistently measured. This study estimated the prevalence and determinants of problematic khat use among Ethiopian adults.\n\nMethodsThis descriptive cross-sectional analysis used baseline data from our Prospective khat cohort study conducted in Butajira and adjacent districts in Central Ethiopia Regional State. We included 504 khat-user participants who had been chewing khat within the previous five years. We assessed problematic khat use using the locally developed and validated 17-item Problematic Khat Use Screening Tool (PKUST-17). A score of [≥]17 indicated problematic use. Binary and multivariable logistic regression models identified associated factors.\n\nResultsAmong the 504 khat-user participants, most were male (82.3%), married (85.0%), and rural residents (70.8%). The prevalence of problematic khat use was 19.6%. Daily or near-daily khat users had eightfold higher odds of problematic use than occasional users (AOR = 8.05, 95% CI: 3.75-17.24). Stressful life events were associated with a 3.48-fold increase (AOR = 3.48, 95% CI: 1.56-7.76), and depressive symptoms with a 3.70-fold increase in odds (AOR = 3.70, 95% CI: 2.00-6.75).\n\nConclusionProblematic khat use affects approximately one in five khat users in Ethiopia. It is strongly associated with frequent khat use, stressful life events, and depression. Longitudinal studies are needed to clarify causal pathways and evaluate culturally appropriate prevention and treatment interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Addis Ababa University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. Sisaye"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1c94mg1jexcbx.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.26.26364894",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26364894v1.full",
  "id": "1c94mg1jexcbx",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26364894v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "addiction medicine"
    ],
    [
      "openalex",
      "2713|Substance Abuse Treatment and Outcomes"
    ]
  ],
  "openalex": "W7223698095",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26364894v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1c94mg1jexcbx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:51Z",
      "native_id": "10.64898/2026.10.26.26364894",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26364894v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:addiction medicine",
      "subfield": "psychiatry"
    }
  ],
  "title": "Prevalence and determinants of problematic khat use in Ethiopia",
  "title_text": "Prevalence and determinants of problematic khat use in Ethiopia",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:51Z",
  "url": "https://research.draconitic.com/paper/1c94mg1jexcbx",
  "venue": "medRxiv",
  "versions": []
}