{ "abstract": "In March 2025, the Japanese Society for Hereditary Tumors and the Ministry of Health, Labour and Welfare (MHLW) Research on Promotion of Cancer Control Program Grant Number JPMH 23EA1037 published the \"Japanese Society for Hereditary Tumors Guidance: Hereditary Cancer Syndromes with Multigene Panel Testing (MGPT), 2025 Edition.\" Unlike conventional phenotype-based guidelines, this guidance promotes preemptive cancer medicine based on genotype. The guidance establishes standardized criteria for MGPT eligibility, emphasizing its utility in both cancer-affected and cancer-free individuals to identify actionable germline pathogenic variants (GPVs). Key recommendations include the integration of gene-specific curation for variant interpretation and the implementation of structured clinical practice systems for risk management. By providing evidence-based management strategies for 56 cancer-susceptibility genes, this guidance facilitates the shift toward genotype-driven oncology. This digest assists healthcare providers in utilizing MGPT and supports shared decision-making for patients and their relatives.", "abstract_shown": true, "affiliations": [ "Department of Medical Genetics and Genomics, Saitama Cancer Center, Saitama, Japan.", "Department of Clinical Genomic Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.", "Aichi Cancer Center Research Institute, Aichi, Japan.", "Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.", "Department of Genome Medical Science and Medical Genetics, Faculty of Medicine, Kagawa University, Kagawa, Japan.", "Department of Clinical Genetics Unit, Shimane University Faculty of Medicine, Shimane, Japan.", "Department of Clinical Genetic Oncology, Cancer Institute Hospital of JFCR, Tokyo, Japan.", "Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.", "Department of Genomic Medicine, Fujita Health University, Aichi, Japan.", "Department of Clinical Genetics, Saitama Medical Center, Saitama Medical University, Saitama, Japan.", "Division of Clinical Genetics/Support Centre for Genetic Medicine, Kanazawa University Hospital, Kanazawa, Japan.", "Department of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan.", "Department of Specialized Surgeries, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.", "Department of Genetic Medicine and Services, National Cancer Center Hospital East, Kashiwa, Japan.", "Department of Genomic Medicine, Mie University Hospital, Tsu, Mie, Japan.", "Department of Life Sciences and Bioethics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.", "Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.", "Department of Clinical Genomics, The University of Tokyo Hospital, Tokyo, Japan.", "Department of Early Clinical Development, Kyoto University Hospital, Kyoto, Japan.", "Department of Medical Genetics and Genomics, Sapporo Medical University School of Medicine, Hokkaido, Japan.", "Department of Laboratory Medicine, National Cancer Center Hospital, Tokyo, Japan.", "Department of Hereditary Tumors, National Hospital Organization Shikoku Cancer Center, Ehime, Japan.", "Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.", "Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.", "Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.", "Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo, Japan.", "Department of Neuro-Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.", "Department of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.", "Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.", "Department of Dermatology, Toyama Prefectural Central Hospital, Toyama, Japan.", "Department of Clinical Genetics, NHO Nagoya Medical Center, Aichi, Japan.", "Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.", "Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.", "Department of Breast and Thyroid Surgery, Kochi Health Science Center, Kochi, Japan.", "Clinical Genetics Unit, Kyoto University Hospital, Kyoto, Japan.", "Cancer Genetics Laboratory, Clinical Research Institute, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.", "Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.", "Laboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.", "Department of Genetic Oncology, Hereditary Tumors, Osaka International Cancer Institute, Osaka, Japan.", "Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada." ], "article_type": null, "arxiv": null, "author_total": 67, "authors": [ { "affs": [ 0 ], "name": "Reiko Yoshida", "orcid": "0000-0001-5146-9472" }, { "affs": [ 1 ], "name": "Akira Hirasawa", "orcid": "0000-0003-4124-5488" }, { "affs": [ 2 ], "name": "Issei Imoto" }, { "affs": [ 3 ], "name": "Tatsuro Yamaguchi", "orcid": "0000-0001-8454-1995" }, { "affs": [ 4 ], "name": "Kensuke Kumamoto" }, { "affs": [ 5 ], "name": "Momoko Araki" }, { "affs": [ 6 ], "name": "Arisa Ueki" }, { "affs": [ 7 ], "name": "Kenta Masuda" }, { "affs": [ 8 ], "name": "Yusaku Urakawa" }, { "affs": [ 9 ], "name": "Noriko Tanabe" }, { "affs": [ 10 ], "name": "Atsushi Watanabe" }, { "affs": [ 11 ], "name": "Makoto Hirata" }, { "affs": [ 12 ], "name": "Tomoyuki Aruga" }, { "affs": [ 13 ], "name": "Takeshi Kuwata" }, { "affs": [ 14 ], "name": "Yoshinaga Okugawa", "orcid": "0000-0002-0417-5559" }, { "affs": [ 6 ], "name": "Keika Kaneko" }, { "affs": [ 15 ], "name": "Hiroko Terui-Kohbata" }, { "affs": [ 16 ], "name": "Megumi Matsumoto" }, { "affs": [ 8 ], "name": "Sayaka Ueno" }, { "affs": [ 17 ], "name": "Katsutoshi Oda" }, { "affs": [ 18 ], "name": "Hisako Ono" }, { "affs": [ 19 ], "name": "Akihiro Sakurai" }, { "affs": [ 20 ], "name": "Hirotaka Matsui", "orcid": "0000-0002-6266-3227" }, { "affs": [ 0 ], "name": "Gou Yamamoto" }, { "affs": [ 1 ], "name": "Hideki Yamamoto" }, { "affs": [ 21 ], "name": "Yasuko Yamamoto" }, { "affs": [ 22 ], "name": "Masachika Ikegami" }, { "affs": [ 23 ], "name": "Yusuke Ohkuma" }, { "affs": [ 24 ], "name": "Kazuhiko Shien", "orcid": "0000-0002-4959-4220" }, { "affs": [ 25 ], "name": "Shigenobu Suzuki" }, { "affs": [ 26 ], "name": "Shunsaku Takayanagi" }, { "affs": [ 27 ], "name": "Masahiko Tanabe", "orcid": "0000-0002-6558-4399" }, { "affs": [ 28 ], "name": "Hisashi Hasumi", "orcid": "0000-0001-8211-8835" }, { "affs": [ 29 ], "name": "Naohito Hatta" }, { "affs": [ 30 ], "name": "Hiroyoshi Hattori", "orcid": "0000-0002-1591-0192" }, { "affs": [ 31 ], "name": "Hiroyuki Matsubayashi", "orcid": "0000-0002-7050-2351" }, { "affs": [ 7 ], "name": "Wataru Yamagami" }, { "affs": [ 32 ], "name": "Masayoshi Yamada" }, { "affs": [ 33 ], "name": "Kazuyuki Oishi" }, { "affs": [ 34 ], "name": "Tomomi Oka" }, { "affs": [ 35 ], "name": "Shinya Oda" }, { "affs": [ 36 ], "name": "Yusuke Kobayashi" }, { "affs": [ 37 ], "name": "Kazuhiro Takekoshi" }, { "affs": [ 38 ], "name": "Takeshi Nakajima" }, { "affs": [ 39 ], "name": "Yoshiko Nakano" }, { "name": "Yoshiko Nakayama" }, { "name": "Fumiharu Miura" }, { "name": "Yasuyuki Miyakura" }, { "name": "Yoshiko Mori" }, { "name": "Akiyo Yoshimura" }, { "affs": [ 37 ], "name": "Masato Yonamine" }, { "name": "Kunitoshi Shigeyasu" }, { "name": "Hiroko Fujita" }, { "affs": [ 1 ], "name": "Mashu Futagawa" }, { "name": "Kouji Ohta" }, { "name": "Junko Kawano" }, { "name": "Tomoharu Tokutomi" }, { "affs": [ 27 ], "name": "Ayaka Sato" }, { "name": "Takeshi Makabe" }, { "affs": [ 7 ], "name": "Tomoko Yoshihama" } ], "bibtex": "https://research.draconitic.com/paper/1caf26qmew82z.bib", "cited_by": 0, "doi": "10.1111/cas.70566", "fulltext_url": "https://europepmc.org/articles/PMC13695384", "id": "1caf26qmew82z", "issns": [ "1347-9032", "1349-7006" ], "landing_url": "https://europepmc.org/article/MED/42925246", "language": "eng", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "1311|BRCA gene mutations in cancer" ] ], "openalex": "W7223469186", "pdf_url": "https://europepmc.org/articles/PMC13695384?pdf=render", "pmcid": "PMC13695384", "pmid": "42925246", "published": "2026-10-24", "publisher": null, "ris": "https://research.draconitic.com/paper/1caf26qmew82z.ris", "sources": [ { "first_seen": "2026-10-30T12:20:33Z", "native_id": "MED:42925246", "source": "europepmc", "url": "https://europepmc.org/article/MED/42925246" } ], "subjects": [ { "field": "biology", "origin": "openalex:1311|BRCA gene mutations in cancer", "subfield": "genetics-genomics" } ], "title": "Japanese Society for Hereditary Tumors Guidance: Hereditary Cancer Syndromes With Multigene Panel Testing, 2025 Edition.", "title_text": "Japanese Society for Hereditary Tumors Guidance: Hereditary Cancer Syndromes With Multigene Panel Testing, 2025 Edition.", "type": "peer-reviewed", "updated_at": "2026-10-30T12:20:33Z", "url": "https://research.draconitic.com/paper/1caf26qmew82z", "venue": "Cancer science", "versions": [] }