{
  "abstract": "Background: Diabetes mellitus (DM) is associated with an increased risk of cardiovascular disease, but its relationship with aortic valve calcification (AVC) remains unclear.\n\nObjective: The present study aims to investigate whether the presence of DM is associated with a higher prevalence of AVC.\n\nMethods: This cross-sectional study combines two large multicentre cohorts: Steno INTEN-CT (EUCT2022-500143-21-01) and DANCAVAS (NCT03946410). Participants with available AVC scores assessed by cardiac CT were included in the present study. Propensity score matching was performed to compare participants with DM to those without DM. AVC was analysed as a binary outcome (0 vs >0) using logistic regression with clustering by matched pairs.\n\nResults: After propensity matching of participants with and without DM, 14 182 participants (7091 matched pairs) were included. Mean age was 67±4 years in the no-DM group compared with 66±4 years in the DM group, p<0.001. AVC was present in 54% and 52% of individuals without and with DM, respectively (p=0.003). In a multivariate logistic regression analysis, DM was not associated with higher AVC prevalence (OR=0.88, 95%CI 0.80–0.96, p=0.004) while male sex, older age, higher body mass index, hypertension, smoking, higher low density lipoprotein cholesterol and statin use remained independently associated with higher prevalence of AVC. An interaction between statin use and DM was found in the association with AVC (p for interaction 0.018), suggesting a potentially stronger association between statin use and AVC among individuals without DM.\n\nConclusion: In this large cross-sectional cohort of 14,182 individuals without known cardiovascular disease, the presence of DM was not associated with higher prevalence of AVC. Instead, higher prevalence of AVC was independently associated with cardiovascular risk factors that frequently coexist with DM. These findings suggest that the previously reported relationship between DM and AVC may, at least partly, be related to accompanying cardiovascular risk factors rather than DM per se.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology B, Odense University Hospital, Odense, Denmark",
    "Department of Cardiovascular Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA",
    "Department of Clinical Research, University of Southern Denmark, Odense, Denmark",
    "Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark",
    "Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark",
    "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark",
    "Steno Diabetes Center Copenhagen, Herlev, Denmark",
    "Department of Cardiology, Lillebaelt Hospital, Kolding, Region Syddanmark, Denmark",
    "Department of Cardiology, Silkeborg Regional Hospital, Silkeborg, Central Denmark Region, Denmark",
    "Department of Cardiology, Sydvestjysk Sygehus, Esbjerg, Region Syddanmark, Denmark",
    "Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark",
    "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark",
    "Cardiology, Lillebaelt Hospital, Vejle, Region Syddanmark, Denmark",
    "Department of Cardiology, Gødstrup Hospital, Gødstrup, Central Denmark Region, Denmark",
    "Department of Internal Medicine, Holbæk Sygehus, Holbæk, Region Zealand, Denmark",
    "Department of Medicine, Nykobing F Sygehus, Nykobing Falster, Denmark",
    "Department of Cardiothoracic and Vascular Surgery, Elitary Research Centre for Individualized Medicine in Arterial Disease (CIMA), Odense Universitetshospital, Odense, Denmark",
    "Department of Cardiology, Svendborg Sygehus, Svendborg, Region Syddanmark, Denmark",
    "Cardiology, Quebec Heart and Lung Institute, Québec City, Quebec, Canada"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 25,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Amal Haujir",
      "orcid": "0009-0009-5747-6839"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Preman Kumarathurai"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Jacob V Stidsen"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Per Løgstrup Poulsen"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Kristian L Funck"
    },
    {
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        6
      ],
      "name": "Batool JY Mohammad"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Emil Johannes Ravn"
    },
    {
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        0,
        2
      ],
      "name": "Selma Hasific"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Camilla Engelsgaard"
    },
    {
      "affs": [
        7
      ],
      "name": "Remmon Washington"
    },
    {
      "affs": [
        8
      ],
      "name": "Lene Helleskov Madsen"
    },
    {
      "affs": [
        9
      ],
      "name": "Monija Mrgan Hansen"
    },
    {
      "affs": [
        10
      ],
      "name": "Anna Pietraszek"
    },
    {
      "affs": [
        6,
        11
      ],
      "name": "Thomas Kümler"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Elena Calderon"
    },
    {
      "affs": [
        12
      ],
      "name": "Martin Busk"
    },
    {
      "affs": [
        13
      ],
      "name": "Morten Böttcher"
    },
    {
      "affs": [
        14
      ],
      "name": "Michael Hecht Olsen"
    },
    {
      "affs": [
        15
      ],
      "name": "Marek Karon"
    },
    {
      "affs": [
        16
      ],
      "name": "Jes Sanddal Lindholt",
      "orcid": "0000-0001-9536-4488"
    },
    {
      "affs": [
        2,
        17
      ],
      "name": "Jess Lambrechtsen"
    },
    {
      "affs": [
        18
      ],
      "name": "Marie-Annick Clavel",
      "orcid": "0000-0002-8924-740X"
    },
    {
      "affs": [
        0
      ],
      "name": "Kristian Altern Øvrehus"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Axel Cosmus Pyndt Diederichsen",
      "orcid": "0000-0002-1285-4826"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jordi Sanchez Dahl"
    }
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  "bibtex": "https://research.draconitic.com/paper/1cdcx6eztwh5p.bib",
  "cited_by": 0,
  "doi": "10.1136/openhrt-2026-004415",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723912/",
  "id": "1cdcx6eztwh5p",
  "issns": [
    "2053-3624"
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  "landing_url": "https://doi.org/10.1136/openhrt-2026-004415",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
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    [
      "heading",
      "Original Research"
    ],
    [
      "heading",
      "Valvular Heart Disease"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
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  "pdf_url": "https://openheart.bmj.com/content/13/2/e004415.full.pdf",
  "pmcid": "PMC13723912",
  "pmid": "42963060",
  "published": "2026-10-30",
  "publisher": "BMJ Publishing Group",
  "ris": "https://research.draconitic.com/paper/1cdcx6eztwh5p.ris",
  "sources": [
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
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  ],
  "title": "Impact of diabetes mellitus on aortic valve calcification: a cross-sectional study of two large multicentre cohorts",
  "title_text": "Impact of diabetes mellitus on aortic valve calcification: a cross-sectional study of two large multicentre cohorts",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:38Z",
  "url": "https://research.draconitic.com/paper/1cdcx6eztwh5p",
  "venue": "Open Heart",
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}