{
  "abstract": "Background: Adherence to immunosuppressive therapy is crucial for successful outcomes in solid organ transplantation. Tacrolimus intra-patient variability (%CV) is a validated marker of adherence and has been associated with graft outcomes. Health literacy (HL), a modifiable factor, may influence this variability, but its role remains unexplored. Methods: We conducted a prospective observational study including adult kidney, liver, and lung transplant recipients receiving tacrolimus. HL was assessed using the Short Test of Functional Health Literacy in Adults (S-TOFHLA); a score <23 indicated insufficient HL. Tacrolimus %CV was calculated over 6 months post-discharge. Linear regression models, adjusted for sociodemographic variables, evaluated the association between HL and %CV. Results: Ninety-eight patients were included (kidney: n = 38, liver: n = 24, lung: n = 36). Patients with insufficient HL had higher %CV than those with sufficient HL (31.5% vs. 16.1%, p < 0.05). HL remained independently associated with %CV after adjusting for age and transplant type (β = -1.60, SE = 0.17, p < 0.05). The final model explained 53% of %CV variability. Conclusions: HL is independently associated with tacrolimus variability. HL screening and targeted educational interventions may help improve medication stability and long-term transplant outcomes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Astrid Bacle"
    },
    {
      "name": "Pauline Blanc-Petitjean"
    },
    {
      "name": "Elouan Demay"
    },
    {
      "name": "Sarah Pelletier"
    },
    {
      "name": "Virginie Migeot"
    },
    {
      "name": "Marie‐claude Langevin"
    },
    {
      "name": "Jean‐philippe Adam"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1ckxj5wa052ve.bib",
  "cited_by": 0,
  "doi": "10.1111/ctr.70304",
  "fulltext_url": null,
  "id": "1ckxj5wa052ve",
  "issns": [
    "0902-0063",
    "1399-0012"
  ],
  "landing_url": "https://hal.science/hal-05399945v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "2714|Medication Adherence and Compliance"
    ]
  ],
  "openalex": "W4416573231",
  "pdf_url": "https://hal.science/hal-05399945/document",
  "pmcid": null,
  "pmid": "41251227",
  "published": "2026-10-06",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/1ckxj5wa052ve.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "hal-05399945",
      "source": "hal",
      "url": "https://hal.science/hal-05399945v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Correlation Between Health Literacy and Tacrolimus Variability in Solid Organ Transplant Recipients",
  "title_text": "Correlation Between Health Literacy and Tacrolimus Variability in Solid Organ Transplant Recipients",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/1ckxj5wa052ve",
  "venue": "Clinical Transplantation",
  "versions": []
}