{
  "abstract": "Introduction\n\nSevere traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. Therapeutic hypothermia may lower intracranial pressure (ICP) and reduce metabolic demand. This study aims to compare mild therapeutic hypothermia with controlled normothermia in adult TBI patients undergoing Barbiturate Coma Therapy (BCT), and to explore artificial intelligence (AI)-assisted prognostic models.Methods\n\nThis single-center, pilot, parallel-group randomized trial evaluates the feasibility and safety of adding mild hypothermia to BCT and explores early signals of benefit or harm. The primary outcome, six-month Glasgow Outcome Scale-Extended (GOSE), is reported descriptively with exact 95% confidence intervals. Secondary outcomes include Cerebral Performance Category, mortality, duration of mechanical ventilation and vasopressor use, intensive care unit (ICU)/hospital length of stay, complications, and physiological/laboratory trends. An exploratory AI-assisted substudy (using prospectively collected clinical, radiological, physiological, and laboratory data) applies LASSO regression to admission predictors of six-month unfavorable outcome and mortality.",
  "abstract_shown": true,
  "affiliations": [
    "Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Department of Neurosurgery, Imam Reza General Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Clinical Research Development Unit, Imam Reza General Hospital, Tabriz, Iran.",
    "Tabriz Health Services Management Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Resuscitation and Critical Care Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Department of Radiology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.",
    "Emergency and Trauma Care Research Center, Imam Reza General Hospital, Tabriz University of Medical Sciences, Tabriz, Iran."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alireza Motamedi"
    },
    {
      "affs": [
        1
      ],
      "name": "Mojtaba Mohammadzadeh Lame"
    },
    {
      "affs": [
        2
      ],
      "name": "Firooz Salehpour"
    },
    {
      "affs": [
        3
      ],
      "name": "Sima Zohrabi"
    },
    {
      "affs": [
        4
      ],
      "name": "Leila Nikniaz"
    },
    {
      "affs": [
        5
      ],
      "name": "Ata Mahmoodpoor"
    },
    {
      "affs": [
        6
      ],
      "name": "Hadi Hamishehkar"
    },
    {
      "affs": [
        7
      ],
      "name": "Saeed Pirmoradi"
    },
    {
      "affs": [
        7
      ],
      "name": "Robab Mehdizadeh Esfanjani"
    },
    {
      "affs": [
        8
      ],
      "name": "Maryam Soleimanpour"
    },
    {
      "affs": [
        9
      ],
      "name": "Amir Vahedi"
    },
    {
      "affs": [
        10
      ],
      "name": "Reza Javadrashid"
    },
    {
      "affs": [
        11
      ],
      "name": "Hassan Soleimanpour"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1cr7qdzbzkv5n.bib",
  "cited_by": 0,
  "doi": "10.22037/aaem.v14i1.3054",
  "fulltext_url": "https://europepmc.org/articles/PMC13704286",
  "id": "1cr7qdzbzkv5n",
  "issns": [
    "2645-4904"
  ],
  "landing_url": "https://europepmc.org/article/MED/42936306",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Traumatic Brain Injury and Neurovascular Disturbances"
    ]
  ],
  "openalex": "W7213235190",
  "pdf_url": "https://europepmc.org/articles/PMC13704286?pdf=render",
  "pmcid": "PMC13704286",
  "pmid": "42936306",
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1cr7qdzbzkv5n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42936306",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42936306"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Traumatic Brain Injury and Neurovascular Disturbances",
      "subfield": "neurology"
    }
  ],
  "title": "Mild Hypothermia Versus Normothermia During Barbiturate Coma Therapy After Severe Traumatic Brain Injury: Protocol for a Randomized Controlled Trial.",
  "title_text": "Mild Hypothermia Versus Normothermia During Barbiturate Coma Therapy After Severe Traumatic Brain Injury: Protocol for a Randomized Controlled Trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/1cr7qdzbzkv5n",
  "venue": "Archives of academic emergency medicine",
  "versions": []
}