{
  "abstract": "Background: Dermatomyositis (DM) is associated with a substantially elevated risk of malignancy, yet the cutaneous features predictive of cancer risk in adults remain insufficiently defined.\n\nObjectives: This study aimed to characterize cutaneous manifestations and clinical factors associated with malignancy in adult DM, with a focus on malignant erythema.\n\nMethods: This retrospective cohort study included 261 adults with DM admitted between 2016 and 2023 and followed up till June 2025. Clinical data, laboratory indicators (including creatine kinase [CK] and lactate dehydrogenase [LDH]), autoantibodies, and skin findings were systematically evaluated. The primary outcome was the occurrence of malignant tumors.\n\nResults: Twenty‑six patients (10%) developed malignancy. Malignant erythema was identified in 35 patients (13.3%), among whom 14 (40%) had malignancy. Both anti-transcription intermediary factor-1 γ (anti-TIF-1 γ) antibodies and malignant erythema were independently associated with malignancy (odds ratio [OR] = 18.231, 95% confidence interval [CI] 4.568–72.756, P < 0.001; OR = 17.588, 95% CI 2.151–143.824, P = 0.007). Malignant erythema demonstrated higher specificity for tumor prediction than anti-TIF-1 γ antibodies (91.1% vs. 86%, P < 0.001), while sensitivity did not differ significantly (53.8% vs. 73.1%, P = 0.190). while.\n\nConclusion: Malignant erythema is a distinctive poikilodermatous manifestation strongly associated with malignancy in adult DM. Its high specificity suggests that malignant erythema may serve as a valuable clinical indicator for malignancy risk and a useful complement to anti-TIF-1 γ antibody testing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, Capital Medical University Affiliated Beijing Shijitan Hospital , ,",
    "Department of Dermatology, First Medical Centre of Chinese People's Liberation Army (PLA) General Hospital , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaojing Xing"
    },
    {
      "affs": [
        1
      ],
      "name": "Zihang Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Biwen Lin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1cy7je3zx2asp.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1960856",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661934/?tool=EBI",
  "id": "1cy7je3zx2asp",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13661934",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Inflammatory Myopathies and Dermatomyositis"
    ]
  ],
  "openalex": "W7214890638",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661934/pdf/?tool=EBI",
  "pmcid": "PMC13661934",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/1cy7je3zx2asp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "PMC:PMC13661934",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13661934"
    },
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1960856",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1960856/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Inflammatory Myopathies and Dermatomyositis",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Malignant erythema as a high-specificity cutaneous indicator of malignancy in adult dermatomyositis: a retrospective cohort study",
  "title_text": "Malignant erythema as a high-specificity cutaneous indicator of malignancy in adult dermatomyositis: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:15Z",
  "url": "https://research.draconitic.com/paper/1cy7je3zx2asp",
  "venue": "Frontiers in immunology",
  "versions": []
}