{
  "abstract": "Osteosarcoma, the most prevalent primary bone tumor, predominantly influences children and adolescents. The pre-metastatic niche (PMN) is a specialized microenvironment that forms before clinically detectable metastatic lesions. Cancer-associated fibroblasts (CAFs) play a crucial function in triggering lung metastasis by coordinating PMN formation in the lung. We found that circRNA_102619, delivered by osteosarcoma-derived extracellular vesicles (EVs), promotes the reprogramming of lung fibroblasts (LFs) into CAFs and PMN formation both in vitro and in vivo. High-throughput protein array analysis revealed that CXCL10, a critical factor secreted by CAFs, drives osteosarcoma proliferation, migration, and resistance to natural killer (NK) cell cytotoxicity. Additionally, circRNA_102619 acts as a sponge for miR-330-3p, thereby controlling CXCL10 production. Importantly, in vivo studies confirmed that osteosarcoma-derived EVs enhance lung PMN formation, promoting osteosarcoma progression and metastasis. Inhibiting osteosarcoma-derived EVs represents a novel strategy to block osteosarcoma progression and metastasis.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medicine, China Medical University, Taichung 40402, Taiwan",
    "Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan",
    "Program for Cancer Biology and Drug Discovery, China Medical University, Taichung 40402, Taiwan",
    "Department of Medicine Research, China Medical University Beigang Hospital, Yunlin 65152, Taiwan",
    "Department of Orthopedic Surgery, China Medical University Hospital, Taichung 40447, Taiwan",
    "School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan",
    "Department of Neurosurgery, China Medical University Hospital, Taichung 40447, Taiwan",
    "Department of Pharmacology, School of Medicine, China Medical University, Taichung 40402, Taiwan",
    "Department of Sports Medicine, College of Health Care, China Medical University, Taichung 40402, Taiwan",
    "Department of Orthopedic Surgery, China Medical University Beigang Hospital, Yunlin 65152, Taiwan",
    "Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan",
    "Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ming-Yu Lien"
    },
    {
      "affs": [
        2
      ],
      "name": "Yu-Hsiang Chang"
    },
    {
      "affs": [
        3
      ],
      "name": "Hsiao-Chi Tsai"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Chin-Jung Hsu"
    },
    {
      "affs": [
        6
      ],
      "name": "Chun-Lin Liu"
    },
    {
      "affs": [
        6
      ],
      "name": "Jeng-Hung Guo"
    },
    {
      "affs": [
        4
      ],
      "name": "Tsung-Yu Ho"
    },
    {
      "affs": [
        7
      ],
      "name": "Liang-Wei Lin",
      "orcid": "0000-0002-6371-8090"
    },
    {
      "affs": [
        4,
        8,
        9
      ],
      "name": "Yi-Chin Fong"
    },
    {
      "affs": [
        0,
        2,
        7,
        10,
        11
      ],
      "name": "Chih-Hsin Tang",
      "orcid": "0000-0002-7113-8352"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1d1se15g423hf.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209193",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13704919/?tool=EBI",
  "id": "1d1se15g423hf",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9193",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Circular RNAs in diseases"
    ]
  ],
  "openalex": "W7222746514",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13704919/pdf/?tool=EBI",
  "pmcid": "PMC13704919",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/1d1se15g423hf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209193",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9193"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13704919",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13704919"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Circular RNAs in diseases",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Exosomal CircRNA_102619–miR-330-3p Interaction Regulates Osteosarcoma Progression and Metastasis by Forming the Lung Pre-Metastatic Niche",
  "title_text": "Exosomal CircRNA_102619–miR-330-3p Interaction Regulates Osteosarcoma Progression and Metastasis by Forming the Lung Pre-Metastatic Niche",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/1d1se15g423hf",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}