{
  "abstract": "Study objective: Calcific aortic stenosis (AS) is the most prevalent type of AS in developed countries. However, in developing countries, rheumatic heart disease (RHD), which has a low progression rate, remains the prevalent type. This study compared the progression rates of AS between the National Guard cohort and Western populations. Design: This was a retrospective single-center cohort study. Participants: Involving patients who underwent two echocardiographic examinations within an interval of at least 2 years. Main outcome measures: Progression of aortic valve stenosis was assessed by measuring changes in the aortic valve area (AVA), peak aortic velocity, and mean aortic valve gradient. Results: In total, 1669 patients (median follow-up: 6.9 years) were included in the analysis. The overall annual AVA progression rate was 0.074 ± 0.1 cm 2 /year (median: −0.061 cm 2 /year). Patients with RHD had lower progression rates than those without RHD (25%–35%; AVA: −0.036 [−0.042, −0.030] cm 2 /year). Patients with end-stage renal disease (ESRD) who exhibited calcific AS had the highest progression rate (AVA: −0.102 ± 0.096 cm 2 /year). The overall progression rate of AS for the National Guard cohort was lower across all groups compared with that in Western populations (AVA: −0.08 to 0.12 cm 2 /year). Conclusions: Patients with ESRD who had calcific AS had the highest progression rate. Meanwhile, patients with RHD exhibited the lowest progression rate. The high prevalence of calcific AS in our study shows the importance of adherence to the American College of Cardiology/European Society of Cardiology guidelines for disease management.",
  "abstract_shown": true,
  "affiliations": [
    "Independent researcher, Riyadh, Saudi Arabia",
    "King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Abdulaziz Cardiac Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia",
    "King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Biostatistics and bioinformatics, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia",
    "Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Abdulaziz Cardiac Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia",
    "Sultan Bin Abdulaziz Humanitarian City, Riyadh, Saudi Arabia",
    "MSc Digital Health and Entrepreneurship, University College London, Prince Sultan Cardiac Center, Riyadh, Saudi Arabia",
    "King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Zeinelabdien T. Elsherif"
    },
    {
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        0
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      "name": "Dania Elsherif"
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    {
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        1
      ],
      "name": "Amjad M. Ahmed"
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    {
      "affs": [
        2
      ],
      "name": "Husam I. Ardah"
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    {
      "affs": [
        1
      ],
      "name": "Fawaz Al-Mutairi"
    },
    {
      "affs": [
        3
      ],
      "name": "Safeah Almaghrabi"
    },
    {
      "affs": [
        3
      ],
      "name": "Futun Alanazi"
    },
    {
      "affs": [
        4
      ],
      "name": "Hind Alaqeel"
    },
    {
      "affs": [
        5
      ],
      "name": "Mashael Almohaimeed"
    },
    {
      "affs": [
        3
      ],
      "name": "Rana Alklaib"
    },
    {
      "affs": [
        6
      ],
      "name": "Jawza Aldakhil"
    },
    {
      "affs": [
        3
      ],
      "name": "Haifa Alturki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1d63jvpxkxga7.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ahjo.2026.100976",
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  "landing_url": "https://doi.org/10.1016/j.ahjo.2026.100976",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
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      "openalex",
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  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718674/pdf/?tool=EBI",
  "pmcid": "PMC13718674",
  "pmid": "42959928",
  "published": "2026-10-20",
  "publisher": "Elsevier",
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  "title": "Progression rates of aortic stenosis in patients with calcific and rheumatic heart disease in Saudi Arabia",
  "title_text": "Progression rates of aortic stenosis in patients with calcific and rheumatic heart disease in Saudi Arabia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:39Z",
  "url": "https://research.draconitic.com/paper/1d63jvpxkxga7",
  "venue": "American Heart Journal Plus",
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}