{
  "abstract": "In this manuscript, we report a straightforward route to spirooxindoles by Pd-catalyzed cycloadditions of 5-vinyloxazolidine-2,4-diones with isatins. After a screening of chiral ligands, DTBM-SEGPHOS was selected to induce high diastereo- and enantiocontrol of the two newly created tetrasubstituted stereocenters. Our investigation demonstrated broad functional group tolerance under the reaction conditions. Overall, this work represents a rare example of Pd-catalyzed cycloadditions involving 5- vinyloxazolidine-2,4-diones and electrophilic C=O bonds.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratoire de Synthèse Organique",
    "UMR 7652, CNRS, Ecole Polytechnique, ENSTA Paris, Institut Polytechnique de Paris",
    "Laboratoire de Chimie Moléculaire, UMR 9168, CNRS, Ecole Polytechnique",
    "Institut Polytechnique de Paris"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xavier Xancho"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pinar Yildirim"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Nicolas Casaretto"
    },
    {
      "name": "Alexis Archambeau",
      "orcid": "0000-0002-1311-503X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1d7fkj9ks9vp7.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010174/v1",
  "fulltext_url": null,
  "id": "1d7fkj9ks9vp7",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010174/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Asymmetric Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7221077957",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010174/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/1d7fkj9ks9vp7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15010174",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010174/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Asymmetric Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Pd-catalyzed Cycloadditions of 5-Vinyloxazolidine-2,4-diones: A Diastereo- and Enantioselective Access to Spirooxindoles",
  "title_text": "Pd-catalyzed Cycloadditions of 5-Vinyloxazolidine-2,4-diones: A Diastereo- and Enantioselective Access to Spirooxindoles",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/1d7fkj9ks9vp7",
  "venue": "ChemRxiv",
  "versions": []
}