{
  "abstract": "目的分析信号转导及转录活化因子3（STAT3）在反复不明原因自然流产患者血清中的表达及与T淋巴细胞亚群、Th17/Treg失衡的关系。方法选取2022年8月至2024年8月在秦皇岛市第一医院治疗的60例反复不明原因自然流产患者作为流产组，另选取58例自愿终止妊娠孕妇作为早孕组，选取55例健康非孕妇女作为非孕组。检测各组患者血清STAT3、T淋巴细胞亚群水平、Th17细胞、Treg细胞水平、Th17/Treg比值，多因素分析反复不明原因自然流产的影响因素。结果非孕组、早孕组血清STAT3、CD3+、CD4+、CD8+水平、外周血Th17细胞、Treg细胞、Th17/Treg比值对比，差异无统计学意义（P>0.05）；与非孕组、早孕组相比，流产组血清STAT3、CD3+、CD4+水平、外周血Th17细胞水平、Th17/Treg比值升高，CD8+水平、外周血Treg细胞水平降低（P<0.05）。Pearson相关性分析结果显示，血清STAT3与CD3+、CD4+、外周血Th17细胞水平、Th17/Treg比值呈正相关，与CD8+、外周血Treg细胞呈负相关（P<0.05）。多因素Logistics回归分析显示，STAT3、CD3+、CD4+、CD8+、Th17、Treg、Th17/Treg为影响反复不明原因自然流产发生的危险因素。结论STAT3在反复不明原因自然流产患者体内降低，与T淋巴细胞亚群、Th17/Treg失衡具有一定相关性，检测STAT3、T淋巴细胞亚群、Th17细胞、Treg细胞水平、Th17/Treg比值，可用于判断反复不明原因自然流产的发生。",
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  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "杨旭"
    },
    {
      "name": "魏菊屏"
    },
    {
      "name": "魏敬艳"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1dnw89zwfnhq2.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.015",
  "id": "1dnw89zwfnhq2",
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  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/1dnw89zwfnhq2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:47Z",
      "native_id": "c99a7d0be01c4116ae63aee2dd7f62dc",
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      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.015"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "STAT3在反复不明原因自然流产患者血清中的表达及与T淋巴细胞亚群、Th17/Treg失衡的关系",
  "title_text": "STAT3在反复不明原因自然流产患者血清中的表达及与T淋巴细胞亚群、Th17/Treg失衡的关系",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:47Z",
  "url": "https://research.draconitic.com/paper/1dnw89zwfnhq2",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}