{
  "abstract": "物质成瘾的核心特征在于药物相关线索不仅能够持续占据行为优先级且在长期戒断后迅速诱发强烈心理渴求和复吸行为。既往研究主要从中脑边缘多巴胺系统及前额叶皮质-纹状体环路解释奖赏强化和行为选择机制，但仍难以充分阐明药物相关线索如何在奖赏价值、情绪状态、注意分配和记忆表征之间的异常整合机制。屏状核因其与广泛皮质和皮质下结构之间高度密集的双向连接及在显著性加工和信息整合中的潜在作用，可能参与成瘾相关跨网络调控。现有证据提示，屏状核可能在多个层面影响物质成瘾的关键过程：参与药物相关线索显著性赋值和奖赏记忆编码；通过与前额叶的双向连接调节皮质信息传递和执行控制功能，从而影响冲动反应和觅药行为；与边缘系统的交互可能参与戒断相关消极情绪的维持，从而影响复吸易感性。此外，致幻剂相关研究为理解屏状核相关网络的可塑性调节提供了补充视角。综上，屏状核可能作为连接奖赏加工、认知控制和情绪记忆的重要跨网络节点，为传统成瘾环路模型提供补充。本文从结构连接基础、临床影像学相关指标及功能机制三个方面对屏状核在物质成瘾中的潜在作用进行系统梳理，并探讨其在复吸预测及干预靶点开发中的转化意义。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "曼青 吴",
      "orcid": "0000-0001-6644-1771"
    },
    {
      "name": "文华 周"
    },
    {
      "name": "敏 赵",
      "orcid": "0000-0001-8382-3050"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1e19qd4rs72zm.bib",
  "cited_by": 0,
  "doi": "10.3724/zdxbyxb-2025-0893",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722852/",
  "id": "1e19qd4rs72zm",
  "issns": [
    "1008-9292"
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  "landing_url": "https://doi.org/10.3724/zdxbyxb-2025-0893",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Monographic Reports"
    ],
    [
      "heading",
      "Q189"
    ],
    [
      "heading",
      "a"
    ],
    [
      "openalex",
      "2804|Neurotransmitter Receptor Influence on Behavior"
    ]
  ],
  "openalex": "W7208776101",
  "pdf_url": null,
  "pmcid": "PMC13722852",
  "pmid": "42695204",
  "published": "2026-09-03",
  "publisher": "Zhejiang University Press",
  "ris": "https://research.draconitic.com/paper/1e19qd4rs72zm.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:36Z",
      "native_id": "PMC13722852",
      "source": "pmc",
      "url": "https://doi.org/10.3724/zdxbyxb-2025-0893"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neurotransmitter Receptor Influence on Behavior",
      "subfield": "neuroscience"
    }
  ],
  "title": "屏状核与物质成瘾的关系研究进展",
  "title_text": "屏状核与物质成瘾的关系研究进展",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:36Z",
  "url": "https://research.draconitic.com/paper/1e19qd4rs72zm",
  "venue": "Journal of Zhejiang University (Medical Sciences)",
  "versions": []
}