{
  "abstract": "Seven known phenolic compounds (2-8) along with one new phenolic compound (1) were isolated from the heartwood of Cotinus coggygria Scop. (Anacardiaceae). Among them, compounds 3-5 are reported from the genus Cotinus for the first time, while compounds 2 and 6-8 are reported from the family Anacardiaceae for the first time. The structure of the new compound was elucidated by detailed spectroscopic analysis, including HR-ESI-MS, 1D, and 2D NMR experiments. In vitro assays showed that compound 1 attenuated glutamate-induced oxidative injury in HT22 cells (EC₅₀ = 3.852 µM, MTS assay) and inhibited TNF-α-induced NF‑κB activation in 293T luciferase reporter cells. Molecular docking suggested that compound 1 may bind to IKKβ, consistent with the observed NF‑κB inhibition. Preliminary structure-activity relationship trend analysis indicated that compounds possessing a 6″-O-rhamnose-containing disaccharide moiety (6-8) showed stronger apparent protective activity than the 6″-O -galloyl derivatives (1-5) under the present assay conditions. These preliminary findings suggest that cotinusin A (1) may warrant further investigation for its potential against glutamate-induced oxidative neuronal injury. However, whether the observed NF‑κB inhibitory activity translates into anti-neuroinflammatory effects in relevant models remains to be determined, and further mechanistic and in vivo studies are needed to establish its therapeutic potential.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, P. R. China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Caiwen Meng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi He"
    },
    {
      "affs": [
        0
      ],
      "name": "Zijia Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyun Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruyi Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoliang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chunlai Zhao",
      "orcid": "0009-0002-8653-1015"
    },
    {
      "affs": [
        0
      ],
      "name": "Meichen Li",
      "orcid": "0000-0003-1717-1247"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1e894d8c18tc0.bib",
  "cited_by": 0,
  "doi": "10.1002/cbdv.71890",
  "fulltext_url": "https://europepmc.org/articles/PMC13724183",
  "id": "1e894d8c18tc0",
  "issns": [
    "1612-1872",
    "1612-1880"
  ],
  "landing_url": "https://europepmc.org/article/MED/42967484",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1110|Phytochemistry and Biological Activities"
    ]
  ],
  "openalex": "W7225037653",
  "pdf_url": "https://europepmc.org/articles/PMC13724183?pdf=render",
  "pmcid": "PMC13724183",
  "pmid": "42967484",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1e894d8c18tc0.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42967484",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42967484"
    },
    {
      "first_seen": "2026-11-04T12:22:41Z",
      "native_id": "PMC13724183",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cbdv.71890"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Phytochemistry and Biological Activities",
      "subfield": "plant-biology"
    }
  ],
  "title": "A Novel Phenolic From the Heartwood of Cotinus coggygria Scop. With Potential Neuroprotective Effects: In Silico and In Vitro Studies.",
  "title_text": "A Novel Phenolic From the Heartwood of Cotinus coggygria Scop. With Potential Neuroprotective Effects: In Silico and In Vitro Studies.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:52Z",
  "url": "https://research.draconitic.com/paper/1e894d8c18tc0",
  "venue": "Chemistry & biodiversity",
  "versions": []
}