{
  "abstract": "Background\n\nProgressive cardiac conduction disease (PCCD) is a rare inherited disorder characterized by degeneration of the His-Purkinje system. Although primarily considered an electrical disease, chronic left bundle branch block (LBBB) may result in mechanical dyssynchrony and reversible cardiomyopathy.Case summary\n\nA 59-year-old man presented with progressive left ventricular (LV) dilation and systolic dysfunction. Electrocardiography showed complete LBBB with a QRS duration of 165 ms. Ischaemic and infiltrative cardiomyopathies were ruled out. Cardiac magnetic resonance imaging revealed LV enlargement without late gadolinium enhancement but with marked mechanical dyssynchrony. Genetic testing identified a likely pathogenic TRPM4 c.393G>C variant, considered contributory to the conduction phenotype. LBBB-induced cardiomyopathy and heart failure with reduced ejection fraction were diagnosed. The patient underwent left bundle branch area pacing (LBBAP)-based cardiac resynchronization therapy. The QRS duration narrowed to 115 ms, and follow-up echocardiography demonstrated marked reverse remodelling with LV ejection fraction improving from 26% to 48%.Discussion\n\nThis case suggests that TRPM4-related PCCD may present with isolated LBBB leading to dyssynchrony-mediated cardiomyopathy. LBBAP can effectively restore electrical synchrony and promote reverse LV remodelling. This favourable response highlights the importance of timely physiological resynchronization in potentially reversible LBBB-related cardiomyopathy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 DaHua Road, Dong Dan, Dongcheng District, Beijing 100730, China.",
    "Arrhythmia Center, Fuwai Shenzhen Hospital, Chinese Academy of Medical Sciences, No. 12 Langshan Road, Nanshan District, Shenzhen 518057, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sijin Wu",
      "orcid": "0000-0003-3278-7218"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyue Wang",
      "orcid": "0000-0001-7264-3513"
    },
    {
      "affs": [
        1
      ],
      "name": "Bin Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Tong Zou",
      "orcid": "0000-0003-2918-2488"
    },
    {
      "affs": [
        0
      ],
      "name": "Xue Yu",
      "orcid": "0000-0002-6633-6055"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1e9f7t2yqfeft.bib",
  "cited_by": 0,
  "doi": "10.1093/ehjcr/ytag718",
  "fulltext_url": "https://europepmc.org/articles/PMC13695054",
  "id": "1e9f7t2yqfeft",
  "issns": [
    "2514-2119"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927274",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiac pacing and defibrillation studies"
    ]
  ],
  "openalex": "W7213916335",
  "pdf_url": "https://europepmc.org/articles/PMC13695054?pdf=render",
  "pmcid": "PMC13695054",
  "pmid": "42927274",
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1e9f7t2yqfeft.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927274",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927274"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac pacing and defibrillation studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "TRPM4-related left bundle branch block-induced cardiomyopathy reversed by left bundle branch area pacing-based cardiac resynchronization therapy: a case report.",
  "title_text": "TRPM4-related left bundle branch block-induced cardiomyopathy reversed by left bundle branch area pacing-based cardiac resynchronization therapy: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/1e9f7t2yqfeft",
  "venue": "European heart journal. Case reports",
  "versions": []
}