{
  "abstract": "Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. Following antigen recognition, IL2 receptor (IL2R) signaling polarizes towards the immunological synapse (IS). However, how IL2 function is integrated during earlier antigen-dependent T cell synapses remains unknown. Here, we employ a supported-lipid bilayer system and TIRF microscopy to monitor the IL2R subunits and their spatiotemporal organization relative to T cell receptor (TCR) at the IS of CD8 ⁺ T cells. We show that TCR and IL2 signaling overlap in space and time and synergize when simultaneously triggered. Using Immuno-STATs, a class of immunotherapeutics in clinical testing that co-deliver IL2 and peptide major histocompatibility complex (pMHC), we demonstrate synergistic TCR and IL2R signaling that drives efficient expansion of antigen-specific CD8 ⁺ T cells. Together, these findings establish the IS as a platform for coordinated cytokine and antigen receptor signaling, providing a mechanistic framework for more selective antigen-specific immunotherapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Jesusa Capera",
      "orcid": "0000-0002-8123-7725"
    },
    {
      "name": "María Navarro-Pérez"
    },
    {
      "name": "Ashwin K. Jainarayanan"
    },
    {
      "name": "Salvatore Valvo",
      "orcid": "0000-0002-5299-1104"
    },
    {
      "name": "Lina Chen",
      "orcid": "0000-0001-6713-2372"
    },
    {
      "name": "Panyu Fei",
      "orcid": "0000-0002-3041-0479"
    },
    {
      "name": "Sarah Flannery"
    },
    {
      "name": "Roman Fischer",
      "orcid": "0000-0002-9715-5951"
    },
    {
      "name": "Saso Cemerski"
    },
    {
      "name": "Simon Low",
      "orcid": "0009-0004-5856-3225"
    },
    {
      "name": "Steven N. Quayle"
    },
    {
      "name": "Raymond J. Moniz"
    },
    {
      "name": "Anish Suri",
      "orcid": "0000-0002-7110-6254"
    },
    {
      "name": "Michael L. Dustin",
      "orcid": "0000-0003-4983-6389"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1eazy1sa5nh7b.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77110-1",
  "fulltext_url": null,
  "id": "1eazy1sa5nh7b",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77110-1",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7220838243",
  "pdf_url": "https://www.nature.com/articles/s41467-026-77110-1_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/1eazy1sa5nh7b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-77110-1",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77110-1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8+ T cells",
  "title_text": "Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8+ T cells",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/1eazy1sa5nh7b",
  "venue": "Nature Communications",
  "versions": []
}