{
  "abstract": "Background\n\nKuanxiong aerosol (KX) has been used in ischemic cardiovascular diseases, but its potential molecular targets and pathway-level associations in post-myocardial infarction heart failure (post-MI HF) remain insufficiently characterized.Objectives\n\nThis study aimed to identify and prioritize putative KX-related molecular targets and signaling pathways associated with post-MI HF by integrating network pharmacology, WGCNA, immune infiltration analysis, and transcriptomic correlation analysis.Materials and methods\n\nWe retrieved KX components from published data, predicted their targets using SwissTargetPrediction, and collected post-MI HF-related genes from GeneCards, OMIM, and DigSee. Using network pharmacology and WGCNA on GSE59867 (80 samples), we screened KX-related targets. Enrichment analyses (KEGG/GSEA) and immune infiltration correlations (ssGSEA) were performed. Key targets were then cross-validated with disease-regulated genes.Results\n\nAmong 215 overlapping targets, calcium, HIF-1, and MAPK signaling were top hits. Two targets, CCR2 and PTPN22, showed significant immune-cell correlations (CCR2 with neutrophils: r=0.62, P<0.001; PTPN22 with NK cells: r=0.48, P<0.05). CCR2 also correlated with MIR21 (r=0.59, P=0.00024) and TTN (r=-0.48, P=0.0039). GSEA linked CCR2 to NOTCH and PTPN22 to PPAR signaling.Conclusion\n\nCCR2 and PTPN22 are credible molecular targets for KX in post-MI HF. From a biotechnology standpoint, these findings support developing targeted immunomodulators (e.g., CCR2 antagonists or PTPN22 activity modulators) or engineered aerosol formulations. Further validation in engineered heart tissue models or bioreactor-based assays is needed before clinical translation.",
  "abstract_shown": true,
  "affiliations": [
    "The Third Central Clinical College of Tianjin Medical University, Tianjin, 300170, China.",
    "Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin, 300170, China.",
    "Artificial Cell Engineering Technology Research Center, Tianjin, 300170, China.",
    "Tianjin Institute of Hepatobiliary Disease, Tianjin, 300170, China.",
    "Department of Heart Center, Tianjin Third Central Hospital, Tianjin, 300170, China.",
    "Department of Cardiovascular Medicine, The Affiliated Tai'an Central Hospital of Qingdao University, Tai'an, Shandong, 271000, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        5
      ],
      "name": "Zhifei Sun"
    },
    {
      "affs": [
        5
      ],
      "name": "Rongzhi Wang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yingwu Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1efd7njej29he.bib",
  "cited_by": 0,
  "doi": "10.30498/ijb.2026.580398.4417",
  "fulltext_url": "https://europepmc.org/articles/PMC13695770",
  "id": "1efd7njej29he",
  "issns": [
    "1728-3043",
    "2322-2921"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928728",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1703|Computational Drug Discovery Methods"
    ]
  ],
  "openalex": "W7223702329",
  "pdf_url": "https://europepmc.org/articles/PMC13695770?pdf=render",
  "pmcid": "PMC13695770",
  "pmid": "42928728",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1efd7njej29he.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928728",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928728"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:F13",
      "subfield": "general"
    }
  ],
  "title": "Targeting CCR2 and PTPN22 Genes for Post-Infarct Heart Failure Therapy: A Network-based Repurposing of Kuanxiong Aerosol.",
  "title_text": "Targeting CCR2 and PTPN22 Genes for Post-Infarct Heart Failure Therapy: A Network-based Repurposing of Kuanxiong Aerosol.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/1efd7njej29he",
  "venue": "Iranian journal of biotechnology",
  "versions": []
}